ReviewNeuroscience and biobehavioral reviews2012
Do initial responses to drugs predict future use or abuse?
Review in Neuroscience and biobehavioral reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
120 citing papers in PubMed, 1 synthesis or guideline pooled it, 180 citations in OpenAlex.
- Inhalation of Alcohol Vapor: Measurement and Implications.Alcoholism, clinical and experimental research · 2017Pooled it
- Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Effects of methamphetamine on two measures of reward: Euphoria and neural activation to reward cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Abuse liability of two electronic nicotine delivery systems compared with combustible cigarettes and nicotine gum from an open-label randomized crossover study.Scientific reports · 2023Trial
- Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults.Psychopharmacology · 2023Trial
- Effect of Δ9-Tetrahydrocannabinol on frontostriatal resting state functional connectivity and subjective euphoric response in healthy young adults.Drug and alcohol dependence · 2021Trial
- Greater analgesic effects of sucrose in the neonate predict greater weight gain to age 18 months.Appetite · 2020Trial
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Neural activation to monetary reward is associated with amphetamine reward sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Trial
- Subjective cannabis effects as part of a developing disorder in adolescents and emerging adults.Journal of abnormal psychology · 2018Trial
- Sweet taste liking is associated with subjective response to amphetamine in women but not men.Psychopharmacology · 2017Trial
- Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Pharmacogenetics of stimulant abuse liability: association of CDH13 variant with amphetamine response in a racially-heterogeneous sample of healthy young adults.Psychopharmacology · 2017Trial
- Trial
- Amphetamine fails to alter cued recollection of emotional images: study of encoding, retrieval, and state-dependency.PloS one · 2014Trial
- Inattention, impulsive action, and subjective response to D-amphetamine.Drug and alcohol dependence · 2013Trial
- Personality and the acute subjective effects of d-amphetamine in humans.Journal of psychopharmacology (Oxford, England) · 2013Trial
- Initial Drug Sensitivity and Vulnerability to Substance Use Disorders: A Review of Individual Influences.Biology · 2026Review
- Etiology of longitudinal associations between subjective effects and substance use disorders in a clinical sample.Addictive behaviors reports · 2026Article
- Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine.Psychopharmacology · 2026Article
60 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Individuals vary in their initial reactions to drugs of abuse in ways that may contribute to the likelihood of subsequent drug use. In humans, most drugs of abuse produce positive subjective states such as euphoria and feelings of well-being, which may facilitate repeated use. In nonhumans, many drugs initially increase locomotor activity and produce discriminative stimulus effects, both of which have been considered to be models of human stimulant and subjective states. Both humans and nonhumans vary in their sensitivity to early acute drug effects in ways that may predict future use or self-administration, and some of these variations appear to be genetic in origin. However, it is not known exactly how the initial responses to drugs in either humans or nonhumans relate to subsequent use or abuse. In humans, positive effects of drugs facilitate continued use of a drug while negative effects discourage use, and in nonhumans, greater genetic risk for drug intake is predicted by reduced sensitivity to drug aversive effects; but whether these initial responses affect escalation of drug use, and the development of dependence is currently unknown. Although early use of a drug is a necessary step in the progression to abuse and dependence, other variables may be of greater importance in the transition from use to abuse. Alternatively, the same variables that predict initial acute drug effects and early use may significantly contribute to continued use, escalation and dependence. Here we review the existing evidence for relations between initial direct drug effects, early use, and continued use. Ultimately, these relations can only be determined from systematic longitudinal studies with comprehensive assessments from early drug responses to progression of problem drug use. In parallel, additional investigation of initial responses in animal models as predictors of drug use will shed light on the underlying mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.