ArticleMaturitas2012
The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis.
Article in Maturitas, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Association Between Vitamin D Deficiency and Cardiovascular Disease Risk Factors in the MENA Population: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Combined effects of vitamin D deficiency and systemic inflammation on all-cause mortality and cause-specific mortality in older adults.BMC geriatrics · 2024Article
- Vitamin D in atherosclerosis and cardiovascular events.European heart journal · 2023Review
- Vitamin D supplementation, cardiac events and stroke: A systematic review and meta-regression analysis.International journal of cardiology. Heart & vasculature · 2020Article
- Vitamin D and cardiovascular disease: an appraisal of the evidence.Clinical chemistry · 2014Review
- Vitamin D in inflammatory diseases.Frontiers in physiology · 2014Review
- Increasing prevalence, changes in diagnostic criteria, and nutritional risk factors for autism spectrum disorders.ISRN nutrition · 2014Review
- Serum 25-hydroxyvitamin D level and extent and complexity of coronary artery disease.Journal of clinical laboratory analysis · 2014Article
- What is the role of vitamin D in autism?Dermato-endocrinology · 2013Article
- The role of the intraplaque vitamin d system in atherogenesis.Scientifica · 2013Review
- Vitamin D deficiency and atrial fibrillation: A cross sectional single center study.ARYA atherosclerosisArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe activated vitamin D receptor (VDR) may have an important role in vascular health. The objective of this study was to determine whether there is an association between the expression of VDRs in coronary arteries and the extent of diet-induced atherosclerosis.
methodsUtilizing a cohort of 39 postmenopausal female cynomolgus monkeys with varying stages of atherosclerosis, histologic sections of the left anterior descending artery (LAD) were analyzed for plaque cross-sectional area, plaque thickness, and VDR quantity using immunohistochemical H-score analysis. The quantities of VDRs were analyzed as a continuous variable and were divided at the median intimal H-score into high vs. low groupings.
resultsIn the LAD, a significant negative correlation was observed between the quantity of VDR and plaque size (both cross-sectional area [p<0.001] and plaque thickness [p<0.001]). Monkeys in the low VDR group had a significantly greater cross-sectional plaque area (1.2mm(2)) and greater plaque thickness (0.3mm) than those in the high VDR group (0.4mm(2), p=0.005; 0.1mm, p=0.003, respectively).
conclusionsLower concentrations of VDRs in a main coronary artery were associated with greater atherosclerotic plaque size in postmenopausal female monkeys. Given that coronary artery atherosclerosis is a major cause of coronary heart disease in postmenopausal women, further research to ascertain the relationship between VDRs and atherosclerosis is warranted.
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Registered trials
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