ReviewSeminars in arthritis and rheumatism2012
Magnetic resonance imaging of subchondral bone marrow lesions in association with osteoarthritis.
Review in Seminars in arthritis and rheumatism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.
- The impact of Yoga on patients with knee osteoarthritis: A systematic review and meta-analysis of randomized controlled trials.PloS one · 2024Pooled it
- Evaluation of treatment parameters for focused-extracorporeal shock wave therapy in knee osteoarthritis patients with bone marrow lesions: a pilot study.Journal of rehabilitation medicine · 2024Trial
- Musculoskeletal ultrasound in symptomatic thumb-base osteoarthritis: clinical, functional, radiological and muscle strength associations.BMC musculoskeletal disorders · 2019Trial
- Trial
- Subchondral bone abnormalities in the knee: imaging techniques, regional anatomy, and pathology.Skeletal radiology · 2026Review
- The role of the AMPK/NLRP3 axis in osteoarthritic bone marrow lesions of the knee: from molecular mechanisms to clinical applications.Journal of molecular histology · 2026Review
- Micro-computed tomographical and histopathological analyses of medial tibial plateaus from patients with subchondral insufficiency fracture or osteoarthritis of the knee.Arthritis research & therapy · 2026Article
- Article
- Osteoimmune senescence in aging-related bone diseases.Frontiers in immunology · 2026Review
- Rethinking the role of cartilage loss: the influence of intra- and extra-articular factors on symptoms in advanced knee osteoarthritis.Bone & joint open · 2025Article
- Comparative outcome analyses of subchondralWorld journal of experimental medicine · 2025Article
- The Warm Phase of CRPS Type-1: Is It Time to Review the Budapest Criteria?Diagnostics (Basel, Switzerland) · 2025Article
- Bone marrow lesions in osteoarthritis: biomarker or treatment target? A narrative review.Skeletal radiology · 2025Review
- Bone marrow edema of the knee: a narrative review.Archives of orthopaedic and trauma surgery · 2024Review
- Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study.BMC complementary medicine and therapies · 2024Article
- Bone marrow edema of the hip: a narrative review.Archives of orthopaedic and trauma surgery · 2023Review
- Bone Remodeling in Osteoarthritis-Biological and Radiological Aspects.Medicina (Kaunas, Lithuania) · 2023Review
- Debate: Intra-articular steroid injections for osteoarthritis - harmful or helpful?Osteoarthritis imaging · 2023Article
- Bone marrow lesions: plugging the holes in our knowledge using animal models.Nature reviews. Rheumatology · 2023Review
- Bone marrow lesions in osteoarthritis: From basic science to clinical implications.Bone reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
objectivesThis nonsystematic literature review provides an overview of magnetic resonance imaging (MRI) of subchondral bone marrow lesions (BMLs) in association with osteoarthritis (OA), with particular attention to the selection of MRI sequences and semiquantitative scoring systems, characteristic morphology, and differential diagnosis. Histologic basis, natural history, and clinical significance are also briefly discussed.
methodsPubMed was searched for articles published up to 2011, using the keywords bone marrow lesion, osteoarthritis, magnetic resonance imaging, bone marrow edema, histology, pain, and subchondral.
resultsBMLs in association with OA correspond to fibrosis, necrosis, edema, and bleeding of fatty marrow as well as abnormal trabeculae on histopathology. Lesions may fluctuate in size within a short time and are associated with the progression of articular cartilage loss and fluctuation of pain in knee OA. The characteristic subchondral edema-like signal intensity of BMLs should be assessed using T2-weighted, proton density-weighted, intermediate-weighted fat-suppressed fast spin echo or short tau inversion recovery. Several semiquantitative scoring systems are available to characterize and grade the severity of BMLs. Quantitative approaches have also been introduced. Differential diagnoses of degenerative BMLs include a variety of traumatic or nontraumatic pathologies that may appear similar to OA-related BMLs on MRI.
conclusionsSubchondral BMLs are a common imaging feature of OA with clinical significance and typical signal alteration patterns, which can be assessed and graded by semiquantitative scoring systems using sensitive MRI sequences.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.