Evidence map›Paper›PMID 22542174›Full record

ArticleNeuron2012

The CAP-Gly of p150: one domain, two diseases, and a function at the end.

Michelle A Cronin, Thomas L Schwarz

Open access · bronzeAbstract readComment
In one paragraph

Article in Neuron, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. A novel Q93H missense mutation in DCTN1 caused distal hereditary motor neuropathy type 7B and Perry syndrome from a Chinese family.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  3. Conformational Flexibility of p150Biophysical journal · 2019
    Article
  4. Structural basis for the extended CAP-Gly domains of p150(glued) binding to microtubules and the implication for tubulin dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michelle A CroninF.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA 02115, USA.
Thomas L Schwarz
Boston Children's Hospital · US

Funding

Milton/Trak 1/2 Protein and the Transport of MitochondriaR01GM069808 · NIGMS · CHILDREN'S HOSPITAL BOSTON · PI SCHWARZ, THOMAS L. · 2004 to 2022
$5.2M
Genetic Analysis of Axonal Transport in SynaptogenesisR01MH075058 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI SCHWARZ, THOMAS L. · 2006 to 2010
$1.8M
Retrograde Motility of MitochondriaF32NS065565 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI CRONIN, MICHELLE AUDREY · 2010 to 2011
$99k
NIGMS NIH HHS R01 GM069808NIMH NIH HHS R01 MH075058NINDS NIH HHS F32 NS065565
6 · The paper itself

Abstract

In this issue of Neuron, work from Moughamian and Holzbaur (2012) and Lloyd et al. (2012) reveals a role for p150 in initiation of retrograde transport at synaptic terminals. These studies also suggest how mutations of p150's CAP-Gly domain lead to both Perry syndrome and HMN7B disease.

Identifiers

PMID22542174
PMCPMC4195236
OpenAlexW2053691144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.