ArticleBioorganic & medicinal chemistry letters2012
Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.
Article in Bioorganic & medicinal chemistry letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- A Catalytic Asymmetric Pictet-Spengler Platform as a Biomimetic Diversification Strategy toward Naturally Occurring Alkaloids.Journal of the American Chemical Society · 2022Article
- Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine.Journal of the American Chemical Society · 2021Article
- Photoinduced Skeletal Rearrangement ofThe Journal of organic chemistry · 2021Article
- Article
- Synthesis and Antiproliferative Screening Of Novel Analogs of Regioselectively Demethylated Colchicine and Thiocolchicine.Molecules (Basel, Switzerland) · 2020Article
- Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.Cells · 2018Article
- Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings.Nature communications · 2016Article
- New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.ACS medicinal chemistry letters · 2016Article
- Reviewing Colchicaceae alkaloids - perspectives of evolution on medicinal chemistry.Current topics in medicinal chemistry · 2014Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.