ArticleArthritis research & therapy2012
The renal urate transporter SLC17A1 locus: confirmation of association with gout.
Article in Arthritis research & therapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 6 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
- GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.Annals of the rheumatic diseases · 2017Pooled it
- Association analysis of the beta-3 adrenergic receptor Trp64Arg (rs4994) polymorphism with urate and gout.Rheumatology international · 2016Pooled it
- Modulation of genetic associations with serum urate levels by body-mass-index in humans.PloS one · 2015Pooled it
- A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk.International journal of clinical and experimental pathology · 2015Pooled it
- Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption.Arthritis research & therapy · 2013Pooled it
- Conducting genetic epidemiology research on hyperuricaemia and gout in an indigenous community in Guam - a feasibility study.BMC public health · 2025Article
- Genomic Variants Associated with Haematological Parameters and T Lymphocyte Subpopulations in a Large White and Min Pig Intercross Population.Animals : an open access journal from MDPI · 2024Article
- A Genome-Wide Association Study of Oxypurinol Concentrations in Patients Treated with Allopurinol.Journal of personalized medicine · 2024Article
- The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications.Frontiers in pharmacology · 2024Review
- The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics.Clinical and translational science · 2023Article
- Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants.Pharmacogenomics and personalized medicine · 2022Article
- Vitamin D pathway gene variation rs3740165 is associated with serological uric acid levels in healthy Chinese women.Frontiers in endocrinology · 2022Article
- Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia.Frontiers in pharmacology · 2021Article
- Promising Epigenetic Biomarkers Associated With Cancer-Associated-Fibroblasts for Progression of Kidney Renal Clear Cell Carcinoma.Frontiers in genetics · 2021Article
- The effect of polymorphism of uric acid transporters on uric acid transport.Journal of nephrology · 2019Review
- The SLC transporter in nutrient and metabolic sensing, regulation, and drug development.Journal of molecular cell biology · 2019Article
- An update on the genetics of hyperuricaemia and gout.Nature reviews. Rheumatology · 2018Review
- Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.The open rheumatology journal · 2018Review
- Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout.Arthritis research & therapy · 2017Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTwo major gout-causing genes have been identified, the urate transport genes SLC2A9 and ABCG2. Variation within the SLC17A1 locus, which encodes sodium-dependent phosphate transporter 1, a renal transporter of uric acid, has also been associated with serum urate concentration. However, evidence for association with gout is equivocal. We investigated the association of the SLC17A1 locus with gout in New Zealand sample sets.
methodsFive variants (rs1165196, rs1183201, rs9358890, rs3799344, rs12664474) were genotyped across a New Zealand sample set totaling 971 cases and 1,742 controls. Cases were ascertained according to American Rheumatism Association criteria. Two population groups were studied: Caucasian and Polynesian.
resultsAt rs1183201 (SLC17A1), evidence for association with gout was observed in both the Caucasian (odds ratio (OR) = 0.67, P = 3.0 × 10-6) and Polynesian (OR = 0.74, P = 3.0 × 10-3) groups. Meta-analysis confirmed association of rs1183201 with gout at a genome-wide level of significance (OR = 0.70, P = 3.0 × 10-8). Haplotype analysis suggested the presence of a common protective haplotype.
conclusionWe confirm the SLC17A1 locus as the third associated with gout at a genome-wide level of significance.
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