Trial reportVeterinary parasitology2012
Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine.
Trial report in Veterinary parasitology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- A qualitative assessment of the context and enabling environment for the control of Taenia solium infections in endemic settings.PLoS neglected tropical diseases · 2021Pooled it
- Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models.PLoS neglected tropical diseases · 2019Pooled it
- Gut Microbiome Health in Farm Animals and Fish: Implications for Human Health and the Risk of Gastrointestinal Diseases.Microorganisms · 2026Review
- When Appearances Deceive: A Case Report of Neurocysticercosis Masquerading As Tuberculoma.Cureus · 2026Article
- The hidden threat of cysticercosis: A neglected public health problem.Open veterinary journal · 2025Review
- Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.Pathogens (Basel, Switzerland) · 2023Article
- Insights into the diagnosis, vaccines, and control of Taenia solium, a zoonotic, neglected parasite.Parasites & vectors · 2023Review
- Validation of a spatial agent-based model for Taenia solium transmission ("CystiAgent") against a large prospective trial of control strategies in northern Peru.PLoS neglected tropical diseases · 2021Article
- Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole.Infectious diseases of poverty · 2021Article
- Neurocysticercosis: Current Perspectives on Diagnosis and Management.Frontiers in veterinary science · 2021Review
- Mimotope-based antigens as potential vaccine candidates in experimental murine cysticercosis.Parasitology · 2020Article
- Understanding transmission and control of the pork tapeworm with CystiAgent: a spatially explicit agent-based model.Parasites & vectors · 2020Article
- Schistosomiasis vaccine development: update on human clinical trials.Journal of biomedical science · 2020Review
- Barriers to Participation in a Community-Based Program to Control Transmission ofThe American journal of tropical medicine and hygiene · 2018Article
- Identification and Control of Sources ofJournal of veterinary research · 2018Article
- Experimental and Theoretical Approaches To Investigate the Immunogenicity of Taenia solium-Derived KE7 Antigen.Infection and immunity · 2017Article
- A hyperendemic focus of Taenia solium transmission in the Banke District of Nepal.Acta tropica · 2017Article
- Reducing zoonotic and internal parasite burdens in pigs using a pig confinement system.Veterinary world · 2017Article
- Human taeniasis: current insights into prevention and management strategies in endemic countries.Risk management and healthcare policy · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200 μg of each of TSOL16 and TSOL18, plus 5mg Quil-A. Necropsies were performed 7 months after the animals were distributed to the farmers. Vaccination reduced 99.7% and 99.9% (p<0.01) the total number of cysts and the number of viable cysts, respectively. Immunization with the TSOL16-TSOL18 vaccines has the potential to control T. solium transmission in areas where the disease is endemic, reducing the source for tapeworm infections in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.