ArticleBiomaterials2012
Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 45 citations in OpenAlex.
- A guide to functionalisation and bioconjugation strategies to surface-initiated polymer brushes.Chemical communications (Cambridge, England) · 2023Review
- A reductionist approach to determine the effect of cell-cell contact on human epidermal stem cell differentiation.Acta biomaterialia · 2022Article
- Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model.Frontiers in bioengineering and biotechnology · 2022Article
- The Importance of Mimicking Dermal-Epidermal Junction for Skin Tissue Engineering: A Review.Bioengineering (Basel, Switzerland) · 2021Review
- Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness.Acta biomaterialia · 2019Article
- Recent Advances in Engineering the Stem Cell Microniche in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Review
- Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification.Nature cell biology · 2018Article
- A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells.Nature communications · 2017Article
- Review
- Tissue fusion over nonadhering surfaces.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Non-cell-adhesive substrates for printing of arrayed biomaterials.Advanced healthcare materials · 2015Article
- Epithelial bridges maintain tissue integrity during collective cell migration.Nature materials · 2014Article
- Micropatterned dermal-epidermal regeneration matrices create functional niches that enhance epidermal morphogenesis.Acta biomaterialia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Correct tissue architecture is essential for normal physiology, yet there have been few attempts to recreate tissues using micro-patterning. We have used polymer brush micro-engineering to generate a stratified micro-epidermis with fewer than 10 human keratinocytes. Epidermal stem cells are captured on 100 μm diameter circular collagen-coated disks. Within 24 h they assemble a stratified micro-tissue, in which differentiated cells have a central suprabasal location. For rings with a non-adhesive centre of up to 40 μm diameter, cell-cell and cell-matrix adhesive interactions together result in correct micro-epidermis assembly. Assembly requires actin polymerization, adherens junctions and desmosomes, but not myosin II-mediated contractility nor coordinated cell movement. Squamous cell carcinoma cells on micro-patterned rings exhibit disturbed architecture that correlates with the characteristics of the original tumours. The micro-epidermis we have generated provides a new platform for screening drugs that modulate tissue assembly, quantifying tissue stratification and investigating the properties of tumour cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.