ArticleCell2012
Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells.
Article in Cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses.Life science alliance · 2024Article
- Deficient spermiogenesis in mice lackingeLife · 2021Article
- Review
- Rlim/Rnf12, Rex1, and X Chromosome Inactivation.Frontiers in cell and developmental biology · 2019Article
- Article
- Identification of target genes for spermatogenic cell-specific KRAB transcription factor ZFP819 in a male germ cell line.Cell & bioscience · 2017Article
- Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer.Nature cell biology · 2016Article
- Article
- Integrin β4 regulation of PTHrP underlies its contribution to mammary gland development.Developmental biology · 2015Article
- A multi-scale approach reveals that NF-κB cRel enforces a B-cell decision to divide.Molecular systems biology · 2015Article
- Post-natal imprinting: evidence from marsupials.Heredity · 2014Review
- Article
- Known unknowns for allele-specific expression and genomic imprinting effects.F1000prime reports · 2014Review
- Maternal regulation of offspring development in mammals is an ancient adaptation tied to lactation.Applied & translational genomics · 2013Review
- Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling.Molecular biology of the cell · 2013Article
- The origin and evolution of genomic imprinting and viviparity in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Embryo manipulation via assisted reproductive technology and epigenetic asymmetry in mammalian early development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation.Cell research · 2012Article
- Selected imprinting of INS in the marsupial.Epigenetics & chromatin · 2012Article
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
In female mouse embryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic trophoblast cells in the placenta undergo imprinted XCI, silencing exclusively the paternal X chromosome. Initiation of imprinted XCI requires a functional maternal allele of the X-linked gene Rnf12, which encodes the ubiquitin ligase Rnf12/RLIM. We find that knockout (KO) of Rnf12 in female mammary glands inhibits alveolar differentiation and milk production upon pregnancy, with alveolar cells that lack RLIM undergoing apoptosis as they begin to differentiate. Genetic analyses demonstrate that these functions are mediated primarily by the paternal Rnf12 allele due to nonrandom maternal XCI in mammary epithelial cells. These results identify paternal Rnf12/RLIM as a critical survival factor for milk-producing alveolar cells and, together with population models, reveal implications of transgenerational epigenetic inheritance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.