ArticleBMC evolutionary biology2012
Cooperative interactions in the West Nile virus mutant swarm.
Article in BMC evolutionary biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 66 citations in OpenAlex.
- Concepts of RNA virus evolution for the design of better antiviral countermeasures.Nature reviews. Microbiology · 2026Review
- Navigating a Fine Balance: Point-Mutant Cheater Viruses Disrupt the Viral Replication Cycle.Molecular biology and evolution · 2025Article
- Quasispecies productivity.Die Naturwissenschaften · 2024Article
- Identification and characterization of novel lineage 1 Powassan virus strains in New York State.Emerging microbes & infections · 2023Article
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- Vector-virus interaction affects viral loads and co-occurrence.BMC biology · 2022Article
- Review
- Antigenic characterization of influenza and SARS-CoV-2 viruses.Analytical and bioanalytical chemistry · 2022Review
- Assessment of the Risk of Severe Dengue Using Intrahost Viral Population in Dengue Virus Serotype 2 PatientsFrontiers in cellular and infection microbiology · 2022Article
- Experimental Evolution of West Nile Virus at Higher Temperatures Facilitates Broad Adaptation and Increased Genetic Diversity.Viruses · 2021Article
- Rapid protein sequence evolution via compensatory frameshift is widespread in RNA virus genomes.BMC bioinformatics · 2021Article
- Genome Number and Size Polymorphism in Zika Virus Infectious Units.Journal of virology · 2021Article
- Article
- Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Competition between social cheater viruses is driven by mechanistically different cheating strategies.Science advances · 2020Article
- West Nile Virus fidelity modulates the capacity for host cycling and adaptation.The Journal of general virology · 2020Article
- Viral quasispecies.PLoS genetics · 2019Article
- Multiscale analysis for patterns of Zika virus genotype emergence, spread, and consequence.PloS one · 2019Article
- Evolutionary Virology at 40.Genetics · 2018Review
- Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.Annual review of virology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRNA viruses including arthropod-borne viruses (arboviruses) exist as highly genetically diverse mutant swarms within individual hosts. A more complete understanding of the phenotypic correlates of these diverse swarms is needed in order to equate RNA swarm breadth and composition to specific adaptive and evolutionary outcomes.
resultsHere, we determined clonal fitness landscapes of mosquito cell-adapted West Nile virus (WNV) and assessed how altering the capacity for interactions among variants affects mutant swarm dynamics and swarm fitness. Our results demonstrate that although there is significant mutational robustness in the WNV swarm, genetic diversity also corresponds to substantial phenotypic diversity in terms of relative fitness in vitro. In addition, our data demonstrate that increasing levels of co-infection can lead to widespread strain complementation, which acts to maintain high levels of phenotypic and genetic diversity and potentially slow selection for individual variants. Lastly, we show that cooperative interactions may lead to swarm fitness levels which exceed the relative fitness levels of any individual genotype.
conclusionsThese studies demonstrate the profound effects variant interactions can have on arbovirus evolution and adaptation, and provide a baseline by which to study the impact of this phenomenon in natural systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.