ArticleOrganic letters2012
Enhancement of cyclopamine via conjugation with nonmetabolic sugars.
Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls.Microbiology spectrum · 2022Article
- Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents.Frontiers in pharmacology · 2022Article
- Synthesis of MeON-Glycoside Derivatives of Oleanolic Acid by Neoglycosylation and Evaluation of Their Cytotoxicity Against Selected Cancer Cell Lines.Molecules (Basel, Switzerland) · 2021Article
- Potential of Steroidal Alkaloids in Cancer: Perspective Insight Into Structure-Activity Relationships.Frontiers in oncology · 2021Review
- Development of anticancer agents targeting the Hedgehog signaling.Cellular and molecular life sciences : CMLS · 2017Review
- The identification of perillyl alcohol glycosides with improved antiproliferative activity.Journal of medicinal chemistry · 2014Article
- Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads.MedChemComm · 2014Article
- Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor.Chembiochem : a European journal of chemical biology · 2013Article
- Synthesis and antibacterial activity of doxycycline neoglycosides.Journal of natural products · 2013Article
- Glucose conjugation for the specific targeting and treatment of cancer.Chemical science · 2013Article
- Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation.Organic letters · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The Veratrum alkaloid cyclopamine, an inhibitor of cancer stem cell growth, was used as a representative scaffold to evaluate the inhibitory impact of glycosylation with a group of nonmetabolic saccharides, such as d-threose. In a five-step divergent process, a 32-member glycoside library was created and assayed to determine that glycosides of such sugars notably improved the GI50 value of cyclopamine while metabolic sugars, such as d-glucose, did not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.