ArticlePigment cell & melanoma research2012
A prognostic signature of defective p53-dependent G1 checkpoint function in melanoma cell lines.
Article in Pigment cell & melanoma research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Targeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.Pigment cell & melanoma research · 2014Trial
- Bioinformatic Characterization of the Functional and Structural Effect of Single Nucleotide Mutations in Patients with High-Grade Glioma.Biomedicines · 2024Article
- Roles of UVA radiation and DNA damage responses in melanoma pathogenesis.Environmental and molecular mutagenesis · 2018Review
- ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.Cell reports · 2017Article
- Synthetic lethality: emerging targets and opportunities in melanoma.Pigment cell & melanoma research · 2017Review
- Bayesian model of signal rewiring reveals mechanisms of gene dysregulation in acquired drug resistance in breast cancer.PloS one · 2017Article
- Effective intra-S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines.Pigment cell & melanoma research · 2016Article
- Article
- IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Vascular channels formed by subpopulations of PECAM1+ melanoma cells.Nature communications · 2014Article
- Resistance surveillance in a BRAF mutant melanoma patient on long-term BRAF-inhibitor treatment.Melanoma research · 2014Article
- Mechanisms of chromosomal instability in melanoma.Environmental and molecular mutagenesis · 2014Article
- Article
- Frequent MYC coamplification and DNA hypomethylation of multiple genes on 8q in 8p11-p12-amplified breast carcinomas.Oncogenesis · 2014Article
- Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?Cell cycle (Georgetown, Tex.) · 2013Article
- Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.Physiological genomics · 2013Article
- MERTK receptor tyrosine kinase is a therapeutic target in melanoma.The Journal of clinical investigation · 2013Article
- A prognostic signature of G(2) checkpoint function in melanoma cell lines.Cell cycle (Georgetown, Tex.) · 2013Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
Abstract
Melanoma cell lines and normal human melanocytes (NHM) were assayed for p53-dependent G1 checkpoint response to ionizing radiation (IR)-induced DNA damage. Sixty-six percent of melanoma cell lines displayed a defective G1 checkpoint. Checkpoint function was correlated with sensitivity to IR with checkpoint-defective lines being radio-resistant. Microarray analysis identified 316 probes whose expression was correlated with G1 checkpoint function in melanoma lines (P≤0.007) including p53 transactivation targets CDKN1A, DDB2, and RRM2B. The 316 probe list predicted G1 checkpoint function of the melanoma lines with 86% accuracy using a binary analysis and 91% accuracy using a continuous analysis. When applied to microarray data from primary melanomas, the 316 probe list was prognostic of 4-yr distant metastasis-free survival. Thus, p53 function, radio-sensitivity, and metastatic spread may be estimated in melanomas from a signature of gene expression.
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Registered trials
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