ArticleJournal of neurosurgery2012
Unruptured intracranial aneurysms in the Familial Intracranial Aneurysm and International Study of Unruptured Intracranial Aneurysms cohorts: differences in multiplicity and location.
Article in Journal of neurosurgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Patient and aneurysm characteristics in familial intracranial aneurysms. A systematic review and meta-analysis.PloS one · 2019Pooled it
- China Intracranial Aneurysm Project (CIAP): protocol for a registry study on a multidimensional prediction model for rupture risk of unruptured intracranial aneurysms.Journal of translational medicine · 2018Trial
- Automated anatomical labeling of the intracranial arteries via deep learning in computed tomography angiography.Frontiers in physiology · 2023Article
- Prevalence of unruptured intracranial aneurysms among first-degree relatives of Thai patients who had aneurysmal subarachnoid hemorrhage.Surgical neurology international · 2021Article
- Methylation of the CDKN2A Gene Increases the Risk of Brain Arteriovenous Malformations.Journal of molecular neuroscience : MN · 2019Article
- Article
- Incidence of Aneurysmal Subarachnoid Hemorrhage with Procedures Requiring General Anesthesia in Patients with Unruptured Intracranial Aneurysms.Interventional neurology · 2018Article
- A 54-year-old man with 12 intracranial aneurysms and familial subarachnoid hemorrhage: case report.Neurosurgical review · 2016Article
- Risk Factors for the Rupture of Middle Cerebral Artery Bifurcation Aneurysms Using CT Angiography.PloS one · 2016Article
- Endovascular biopsy: Technical feasibility of novel endothelial cell harvesting devices assessed in a rabbit aneurysm model.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2015Article
- Affected twins in the familial intracranial aneurysm study.Cerebrovascular diseases (Basel, Switzerland) · 2015Article
- Lessons learned from whole exome sequencing in multiplex families affected by a complex genetic disorder, intracranial aneurysm.PloS one · 2015Article
- Comparative effectiveness research.AJNR. American journal of neuroradiology · 2014Article
- Factors affecting formation and rupture of intracranial saccular aneurysms.Neurosurgical review · 2014Review
- High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms.PLoS genetics · 2014Article
- Perioperative variables contributing to the rupture of intracranial aneurysm: an update.TheScientificWorldJournal · 2013Review
- Physical factors effecting cerebral aneurysm pathophysiology.Annals of biomedical engineering · 2013Review
- Genetic factors involves in intracranial aneurysms--actualities.Journal of medicine and lifeReview
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
Abstract
objectFamilial predisposition is a recognized nonmodifiable risk factor for the formation and rupture of intracranial aneurysms (IAs). However, data regarding the characteristics of familial IAs are limited. The authors sought to describe familial IAs more fully, and to compare their characteristics with a large cohort of nonfamilial IAs.
methodsThe Familial Intracranial Aneurysm (FIA) study is a multicenter international study with the goal of identifying genetic and other risk factors for formation and rupture of IAs in a highly enriched population. The authors compared the FIA study cohort with the International Study of Unruptured Intracranial Aneurysms (ISUIA) cohort with regard to patient demographic data, IA location, and IA multiplicity. To improve comparability, all patients in the ISUIA who had a family history of IAs or subarachnoid hemorrhage were excluded, as well as all patients in both cohorts who had a ruptured IA prior to study entry.
resultsOf 983 patients enrolled in the FIA study with definite or probable IAs, 511 met the inclusion criteria for this analysis. Of the 4059 patients in the ISUIA study, 983 had a previous IA rupture and 657 of the remainder had a positive family history, leaving 2419 individuals in the analysis. Multiplicity was more common in the FIA patients (35.6% vs 27.9%, p<0.001). The FIA patients had a higher proportion of IAs located in the middle cerebral artery (28.6% vs 24.9%), whereas ISUIA patients had a higher proportion of posterior communicating artery IAs (13.7% vs 8.2%, p=0.016).
conclusionsHeritable structural vulnerability may account for differences in IA multiplicity and location. Important investigations into the underlying genetic mechanisms of IA formation are ongoing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.