ArticleBMC medical genetics2012
Race-ethnic differences in the association of genetic loci with HbA1c levels and mortality in U.S. adults: the third National Health and Nutrition Examination Survey (NHANES III).
Article in BMC medical genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.PloS one · 2017Pooled it
- HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial.Diabetes care · 2015Trial
- Global landscape of kidney health across Indigenous populations.Nature reviews. Nephrology · 2026Review
- Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations.PloS one · 2025Article
- Ethnicity Affects A1C Levels in Patients With Diagnosed Type 2 Diabetes in Southern Israel.Diabetes spectrum : a publication of the American Diabetes Association · 2024Article
- The Role of Early Pregnancy Maternal pGCD59 Levels in Predicting Neonatal Hypoglycemia-Subanalysis of the DALI Study.The Journal of clinical endocrinology and metabolism · 2022Observational
- Race, Biomarkers, and Cardiovascular Disease in Patients With Chronic Kidney Disease.Journal of the American Heart Association · 2022Article
- Article
- Reliability of glycosylated hemoglobin in the diagnosis of gestational diabetes mellitus.Journal of clinical laboratory analysis · 2020Article
- The diagnostic accuracy of HbA1c in detecting gestational diabetes mellitus among Chinese pregnant individuals.Annals of translational medicine · 2020Article
- Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring.Diabetes technology & therapeutics · 2019 · on this mapArticle
- Future Preventive Gene Therapy of Polygenic Diseases from a Population Genetics Perspective.International journal of molecular sciences · 2019Article
- Genetic Ancestry Markers and Difference in A1c Between African American and White in the Diabetes Prevention Program.The Journal of clinical endocrinology and metabolism · 2019Article
- Racial disparity in HbA1c persists when fructosamine is used as a surrogate for mean blood glucose in youth with type 1 diabetes.Pediatric diabetes · 2018Article
- Association of ANK1 variants with new-onset type 2 diabetes in a Han Chinese population from northeast China.Experimental and therapeutic medicine · 2017Article
- Are There Clinical Implications of Racial Differences in HbA1c? Yes, to Not Consider Can Do Great Harm!Diabetes care · 2016Article
- Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people.BMC genetics · 2016Article
- Type 2 Diabetes Genetic Predisposition, Obesity, and All-Cause Mortality Risk in the U.S.: A Multiethnic Analysis.Diabetes care · 2016Article
- Should haemoglobin A1C be used for diagnosis of diabetes mellitus in Malawi?Malawi medical journal : the journal of Medical Association of Malawi · 2016Article
- Gene polymorphisms and gene scores linked to low serum carotenoid status and their associations with metabolic disturbance and depressive symptoms in African-American adults.The British journal of nutrition · 2014Article
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundHemoglobin A1c (HbA1c) levels diagnose diabetes, predict mortality and are associated with ten single nucleotide polymorphisms (SNPs) in white individuals. Genetic associations in other race groups are not known. We tested the hypotheses that there is race-ethnic variation in 1) HbA1c-associated risk allele frequencies (RAFs) for SNPs near SPTA1, HFE, ANK1, HK1, ATP11A, FN3K, TMPRSS6, G6PC2, GCK, MTNR1B; 2) association of SNPs with HbA1c and 3) association of SNPs with mortality.
methodsWe studied 3,041 non-diabetic individuals in the NHANES (National Health and Nutrition Examination Survey) III. We stratified the analysis by race/ethnicity (NHW: non-Hispanic white; NHB: non-Hispanic black; MA: Mexican American) to calculate RAF, calculated a genotype score by adding risk SNPs, and tested associations with SNPs and the genotype score using an additive genetic model, with type 1 error = 0.05.
resultsRAFs varied widely and at six loci race-ethnic differences in RAF were significant (p < 0.0002), with NHB usually the most divergent. For instance, at ATP11A, the SNP RAF was 54% in NHB, 18% in MA and 14% in NHW (p < .0001). The mean genotype score differed by race-ethnicity (NHW: 10.4, NHB: 11.0, MA: 10.7, p < .0001), and was associated with increase in HbA1c in NHW (β = 0.012 HbA1c increase per risk allele, p = 0.04) and MA (β = 0.021, p = 0.005) but not NHB (β = 0.007, p = 0.39). The genotype score was not associated with mortality in any group (NHW: OR (per risk allele increase in mortality) = 1.07, p = 0.09; NHB: OR = 1.04, p = 0.39; MA: OR = 1.03, p = 0.71).
conclusionAt many HbA1c loci in NHANES III there is substantial RAF race-ethnic heterogeneity. The combined impact of common HbA1c-associated variants on HbA1c levels varied by race-ethnicity, but did not influence mortality.
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