ArticleInfection and immunity1990
Production of tumor necrosis factors alpha and beta by human mononuclear leukocytes stimulated with mitogens, bacteria, and malarial parasites.
Article in Infection and immunity, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Complement in malaria: immune evasion strategies and role in protective immunity.FEBS letters · 2020Review
- Differential Gene Expression Profile of Human Neutrophils Cultured withJournal of immunology research · 2018Article
- Cytokines regulate complement receptor immunoglobulin expression and phagocytosis of Candida albicans in human macrophages: A control point in anti-microbial immunity.Scientific reports · 2017Article
- Inhibition of the lipopolysaccharide-induced stimulation of the members of the MAPK family in human monocytes/macrophages by 4-hydroxynonenal, a product of oxidized omega-6 fatty acids.The American journal of pathology · 2008Article
- Dietary inclusion of colicin e1 is effective in preventing postweaning diarrhea caused by F18-positive Escherichia coli in pigs.Antimicrobial agents and chemotherapy · 2007Article
- Pathogenesis of malaria and clinically similar conditions.Clinical microbiology reviews · 2004Review
- Role of ADP-ribosyltransferase activity of pertussis toxin in toxin-adhesin redundancy with filamentous hemagglutinin during Bordetella pertussis infection.Infection and immunity · 2001Article
- Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production.The Journal of clinical investigation · 1997Article
- Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne.Infection and immunity · 1995Article
- Cryptococcus neoformans fails to induce nitric oxide synthase in primed murine macrophage-like cells.Infection and immunity · 1995Article
- Increased plasma levels of soluble IL-2R are associated with severe Plasmodium falciparum malaria.Clinical and experimental immunology · 1994Article
- Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans.Infection and immunity · 1993Article
- Endotoxin-induced tumor necrosis factor alpha synthesis in murine embryo fibroblasts.Infection and immunity · 1993Article
- Effects of cytokines, complement, and antibody on the neutrophil respiratory burst and phagocytic response to Plasmodium falciparum merozoites.Infection and immunity · 1992Article
- Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection.Infection and immunity · 1992Article
- Induction of tumor necrosis factor (TNF) and interleukin-1 (IL-1) by Pseudomonas aeruginosa and exotoxin A-induced suppression of lymphoproliferation and TNF, lymphotoxin, gamma interferon, and IL-1 production in human leukocytes.Infection and immunity · 1992Article
- Bacterial infection modulated by glucan: a search for the host defense potentiation mechanisms.Folia microbiologica · 1992Article
- Article
- Induction of Japanese flounder tnf promoter activity by lipopolysaccharide in zebrafish embryo.Marine biotechnology (New York, N.Y.)Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factors alpha and beta (TNF-alpha and TNF-beta) are multifaceted polypeptide cytokines which may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. Although it is well established that bacterial lipopolysaccharide is a potent inducer of TNF-alpha, there is still very little known of the types of agents which can trigger the production of TNFs in mononuclear leukocytes. Using an enzyme-linked immunosorbent assay for measuring TNF-alpha and TNF-beta, we examined the capacity of various T-lymphocyte and beta-lymphocyte mitogens as well as microbial components to stimulate production of these cytokines in culture. The mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen induced production of both TNF-alpha and TNF-beta, while whole-killed Staphylococcus aureus and Bordetella pertussis, like lipopolysaccharide, were potent inducers of TNF-alpha but failed to stimulate TNF-beta production. TNF-alpha production was detectable within 1 h after stimulation, while TNF-beta production was not detected until after 8 h of culture. The bacterial products tetanus toxoid, purified protein derivative, pertussis filamentous hemagglutinin, and pertussis toxin were all able to induce TNF-alpha and TNF-beta production. Disrupted (frozen-thawed) Plasmodium falciparum-infected erythrocytes were also potent inducers of TNF-alpha and TNF-beta. The results demonstrated that a wide variety of microbial components are inducers of TNF-alpha. Some may not only be more effective than lipopolysaccharide but can also induce TNF-beta production. Furthermore, evidence is presented showing that TNF-beta but not TNF-alpha production correlates with lymphoproliferation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.