ArticlePloS one2012
The expression of irx7 in the inner nuclear layer of zebrafish retina is essential for a proper retinal development and lamination.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Multifaceted role of Iroquois signaling in development and diseases.Molecules and cells · 2025Review
- Polystyrene Nanomicroplastics Aggravate Ammonia-Induced Neurotoxic Effects in Zebrafish Embryos.Toxics · 2024Article
- Leveraging Zebrafish to Study Retinal Degenerations.Frontiers in cell and developmental biology · 2018Review
- A novel subset of enteric neurons revealed by ptf1a:GFP in the developing zebrafish enteric nervous system.Genesis (New York, N.Y. : 2000) · 2016Article
- A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration.PloS one · 2016Article
- Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State.Developmental cell · 2015Article
- Development of Retinal Amacrine Cells and Their Dendritic Stratification.Current ophthalmology reports · 2014Article
- Expression profiling of the RPE in zebrafish smarca4 mutant revealed altered signals that potentially affect RPE and retinal differentiation.Molecular vision · 2014Article
- Insulinoma-associated 1a (Insm1a) is required for photoreceptor differentiation in the zebrafish retina.Developmental biology · 2013Article
- The role of egr1 in early zebrafish retinogenesis.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Irx7, a member in the zebrafish iroquois transcription factor (TF) family, has been shown to control brain patterning. During retinal development, irx7's expression was found to appear exclusively in the inner nuclear layer (INL) as soon as the prospective INL cells withdraw from the cell cycle and during retinal lamination. In Irx7-deficient retinas, the formation of a proper retinal lamination was disrupted and the differentiation of INL cell types, including amacrine, horizontal, bipolar and Muller cells, was compromised. Despite irx7's exclusive expression in the INL, photoreceptors differentiation was also compromised in Irx7-deficient retinas. Compared with other retinal cell types, ganglion cells differentiated relatively well in these retinas, except for their dendritic projections into the inner plexiform layer (IPL). In fact, the neuronal projections of amacrine and bipolar cells into the IPL were also diminished. These indicate that the retinal lamination issue in the Irx7-deficient retinas is likely caused by the attenuation of the neurite outgrowth. Since the expression of known TFs that can specify specific retinal cell type was also altered in Irx7-deficient retinas, thus the irx7 gene network is possibly a novel regulatory circuit for retinal development and lamination.
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