ArticlePloS one2012
Interplay between cell migration and neurite outgrowth determines SH2B1β-enhanced neurite regeneration of differentiated PC12 cells.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Mesenchymal Stem Cell Secretome Attenuates PrPCells · 2025Article
- The dynamic TRPV2 ion channel proximity proteome reveals functional links of calcium flux with cellular adhesion factors NCAM and L1CAM in neurite outgrowth.Cell calcium · 2024Article
- The role of primed and non-primed MSC-derived conditioned media in neuroregeneration.Frontiers in molecular neuroscience · 2023Article
- Article
- Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury.Neural regeneration research · 2022Article
- Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Three-dimensional real time imaging of amyloid β aggregation on living cells.Scientific reports · 2020Article
- Article
- WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Transcription Factor Brn-3b Overexpression Enhances Neurite Outgrowth in PC12 Cells Under Condition of Hypoxia.Cellular and molecular neurobiology · 2015Article
- Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1.Endocrinology · 2014Article
- Receptor for advanced glycation end products (RAGE) and its ligands: focus on spinal cord injury.International journal of molecular sciences · 2014Review
- SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation.Molecular and cellular biology · 2014Article
- HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury.Journal of cellular and molecular medicine · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of neurite outgrowth is crucial in developing strategies to promote neurite regeneration after nerve injury and in degenerative diseases. In this study, we demonstrate that overexpression of an adaptor/scaffolding protein SH2B1β promotes neurite re-growth of differentiated PC12 cells, an established neuronal model, using wound healing (scraping) assays. Cell migration and the subsequent remodeling are crucial determinants during neurite regeneration. We provide evidence suggesting that overexpressing SH2B1β enhances protein kinase C (PKC)-dependent cell migration and phosphatidylinositol 3-kinase (PI3K)-AKT-, mitogen activated protein kinase (MAPK)/extracellular signal-regulated protein kinase (ERK) kinase (MEK)-ERK-dependent neurite re-growth. Our results further reveal a cross-talk between pathways involving PKC and ERK1/2 in regulating neurite re-growth and cell migration. We conclude that temporal regulation of cell migration and neurite outgrowth by SH2B1β contributes to the enhanced regeneration of differentiated PC12 cells.
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Registered trials
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