ArticleFrontiers in genetics2012
Dark matter RNA: an intelligent scaffold for the dynamic regulation of the nuclear information landscape.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Evaluating Performance of Different RNA Secondary Structure Prediction Programs Using Self-cleaving Ribozymes.Genomics, proteomics & bioinformatics · 2024Article
- ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins.eLife · 2024Article
- Epigenetic control of chromosome-associated lncRNA genes essential for replication and stability.Nature communications · 2022Article
- Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans.BMC biology · 2021Article
- Reciprocal monoallelic expression of ASAR lncRNA genes controls replication timing of human chromosome 6.RNA (New York, N.Y.) · 2020Article
- Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.International journal of molecular sciences · 2018Review
- Functional annotation of the vlinc class of non-coding RNAs using systems biology approach.Nucleic acids research · 2016Article
- The Landscape of long noncoding RNA classification.Trends in genetics : TIG · 2015Review
- Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?Frontiers in physiology · 2015Article
- Dark matter RNA illuminates the puzzle of genome-wide association studies.BMC medicine · 2014Article
- Identification and expression of a novel transcript of the growth and differentiation factor-11 gene.Molecular and cellular biochemistry · 2014Article
- Combining DGE and RNA-sequencing data to identify new polyA+ non-coding transcripts in the human genome.Nucleic acids research · 2014Article
- Redundancy of the genetic code enables translational pausing.Frontiers in genetics · 2014Review
- Trans-regulation of RNA-binding protein motifs by microRNA.Frontiers in genetics · 2014Article
- VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer.Genome biology · 2013Article
- Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells.BMC genomics · 2012Article
- The Kcnq1ot1 long non-coding RNA affects chromatin conformation and expression of Kcnq1, but does not regulate its imprinting in the developing heart.PLoS genetics · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Perhaps no other topic in contemporary genomics has inspired such diverse viewpoints as the 95+% of the genome, previously known as "junk DNA," that does not code for proteins. Here, we present a theory in which dark matter RNA plays a role in the generation of a landscape of spatial micro-domains coupled to the information signaling matrix of the nuclear landscape. Within and between these micro-domains, dark matter RNAs additionally function to tether RNA interacting proteins and complexes of many different types, and by doing so, allow for a higher performance of the various processes requiring them at ultra-fast rates. This improves signal to noise characteristics of RNA processing, trafficking, and epigenetic signaling, where competition and differential RNA binding among proteins drives the computational decisions inherent in regulatory events.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.