ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Intrinsic and extrinsic mechanisms control the termination of cortical interneuron migration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024Article
- Interneuron odyssey: molecular mechanisms of tangential migration.Frontiers in neural circuits · 2023Review
- Building thalamic neuronal networks during mouse development.Frontiers in neural circuits · 2023Review
- Dissecting the molecular basis of human interneuron migration in forebrain assembloids from Timothy syndrome.Cell stem cell · 2022Article
- Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.Frontiers in molecular neuroscience · 2022Article
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes.Nature communications · 2021Article
- Temporally regulated cell migration is sensitive to variation in body size.Development (Cambridge, England) · 2021Article
- Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation.Frontiers in cell and developmental biology · 2020Review
- Foxg1 Regulates the Postnatal Development of Cortical Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Review
- PlexinD1 signaling controls morphological changes and migration termination in newborn neurons.The EMBO journal · 2018Article
- The K(+)-Cl(-) Cotransporter KCC2 and Chloride Homeostasis: Potential Therapeutic Target in Acute Central Nervous System Injury.Molecular neurobiology · 2016Review
- From migration to settlement: the pathways, migration modes and dynamics of neurons in the developing brain.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2016Review
- Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia.The European journal of neuroscience · 2015Article
- Prox1 Regulates the Subtype-Specific Development of Caudal Ganglionic Eminence-Derived GABAergic Cortical Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons.Frontiers in cellular neuroscience · 2015Review
- Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex.Frontiers in cellular neuroscience · 2015Review
- Article
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8 authors.
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Abstract
During development, neurons migrate from their site of origin to their final destinations. Upon reaching this destination, the termination of their migration is crucial for building functional architectures such as laminated structures and nuclei. How this termination is regulated, however, is not clear. Here, we investigated the contribution of cell-intrinsic mechanisms and extrinsic factors. Using GAD67-GFP knock-in mice and in utero electroporation cell labeling, we visualized GABAergic neurons and analyzed their motility in vitro. We find that the motility of GABAergic neurons in cortical slices gradually decreases as development proceeds and is almost abolished by the end of the first postnatal week. Consistent with this, a reduction of embryonic interneuron motility occurred in dissociated cultures. This is in part due to cell-intrinsic mechanisms, as a reduction in motility is observed during long-term culturing on glial feeder cells. Cell-intrinsic regulation is further supported by observations that interneurons labeled in early stages migrated more actively than those labeled in late stages in the same cortical explant. We found evidence suggesting that upregulation of the potassium-chloride cotransporter KCC2 underlies this intrinsic regulation. Reduced motility is also observed when embryonic interneurons are plated on postnatal cortical feeder cells, suggesting extrinsic factors derived from the postnatal cortex too contribute to termination. These factors should include secreted molecules, as cultured postnatal cortical cells could exercise this effect without directly contacting the interneuron. These findings suggest that intrinsic mechanisms and extrinsic factors coordinate to reduce the motility of migrating neurons, thereby leading to the termination of migration.
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