ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Effective sensory modality activating an escape triggering neuron switches during early development in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 60 citations in OpenAlex.
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- The early development and physiology ofJournal of neurophysiology · 2021Article
- Developmental Exposure to Domoic Acid Disrupts Startle Response Behavior and Circuitry in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and ΔScientific reports · 2021Article
- D-Amphetamine Exposure Differentially Disrupts Signaling Across Ontogeny in the Zebrafish.Bioelectricity · 2019Article
- Behavioral Role of the Reciprocal Inhibition between a Pair of Mauthner Cells during Fast Escapes in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Development of vestibular behaviors in zebrafish.Current opinion in neurobiology · 2018Review
- Behavior, Electrophysiology, and Robotics Experiments to Study Lateral Line Sensing in Fishes.Integrative and comparative biology · 2018Review
- Principles Governing Locomotion in Vertebrates: Lessons From Zebrafish.Frontiers in neural circuits · 2018Review
- Intensity-dependent timing and precision of startle response latency in larval zebrafish.The Journal of physiology · 2017Article
- Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo.Current biology : CB · 2016Article
- Position- and quantity-dependent responses in zebrafish turning behavior.Scientific reports · 2016Article
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- Defects of the Glycinergic Synapse in Zebrafish.Frontiers in molecular neuroscience · 2016Review
- A convergent and essential interneuron pathway for Mauthner-cell-mediated escapes.Current biology : CB · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing nervous systems grow to integrate sensory signals from different modalities and to respond through various behaviors. Here, we examined the development of escape behavior in zebrafish [45-170 h postfertilization (hpf)] to study how developing sensory inputs are integrated into sensorimotor circuits. Mature fish exhibit fast escape upon both auditory/vestibular (AV) and head-tactile stimuli. Newly hatched larvae, however, do not respond to AV stimuli before 75 hpf. Because AV-induced fast escape in mature fish is triggered by a pair of hindbrain neurons known as Mauthner (M) cells, we studied functional development of the M-cell circuit accounting for late acquisition of AV-induced escape. In fast escape elicited by head-directed water jet, minimum onset latency decreased throughout development (5 ms at 45-59 hpf, 3 ms after 75 hpf). After 75 hpf, lesioning the otic vesicle (OV) to eliminate AV input resulted in loss of short-latency (<5 ms) fast escape, whereas ablation of the sensory trigeminal ganglion (gV) to block head-tactile input did not. Before 75 hpf, however, fast escape persisted after OV lesion but disappeared after gV ablation. Laser ablation of the M-cell and Ca²⁺ imaging of the M-cell during escape demonstrated that M-cell firing is required to initiate short-latency fast escapes at every developmental stage and further suggest that head-tactile input activates the M-cell before 75 hpf, but that after this point AV input activates the M-cell instead. Thus, a switch in the effective sensory input to the M-cells mediates the acquisition of a novel modality for initiating fast escape.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.