ArticleJournal of neurophysiology2012
Analysis of functional neuronal connectivity in the Drosophila brain.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
- An essential experimental control for functional connectivity mapping with optogenetics.Genetics · 2025Article
- Temperature-dependent modulation of light-induced circadian responses in Drosophila melanogaster.The EMBO journal · 2025Article
- High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons.Scientific reports · 2025Article
- Four SpsP neurons are an integrating sleep regulation hub inScience advances · 2024Article
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- A brain-derived insulin signal encodes protein satiety for nutrient-specific feeding inhibition.Cell reports · 2024Article
- Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development.bioRxiv : the preprint server for biology · 2024Article
- Dynamic encoding of temperature in the central circadian circuit coordinates physiological activities.Nature communications · 2024Article
- Rapid threat assessment in the Drosophila thermosensory system.Nature communications · 2023Article
- Developmental emergence of sleep rhythms enables long-term memory inScience advances · 2023Article
- Alleviation of thermal nociception depends on heat-sensitive neurons and a TRP channel in the brain.Current biology : CB · 2023Article
- Enhanced neuroimaging with a calcium sensor inJournal of biomedical optics · 2023Article
- Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.Development (Cambridge, England) · 2023Article
- Cross-modal modulation gates nociceptive inputs in Drosophila.Current biology : CB · 2023Article
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- Polyphasic circadian neural circuits drive differential activities in multiple downstream rhythmic centers.Current biology : CB · 2023Article
- A dedicate sensorimotor circuit enables fine texture discrimination by active touch.PLoS genetics · 2023Article
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- Connectomic analysis of theeLife · 2022Article
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28 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Drosophila melanogaster is a valuable model system for the neural basis of complex behavior, but an inability to routinely interrogate physiologic connections within central neural networks of the fly brain remains a fundamental barrier to progress in the field. To address this problem, we have introduced a simple method of measuring functional connectivity based on the independent expression of the mammalian P2X2 purinoreceptor and genetically encoded Ca(2+) and cAMP sensors within separate genetically defined subsets of neurons in the adult brain. We show that such independent expression is capable of specifically rendering defined sets of neurons excitable by pulses of bath-applied ATP in a manner compatible with high-resolution Ca(2+) and cAMP imaging in putative follower neurons. Furthermore, we establish that this approach is sufficiently sensitive for the detection of excitatory and modulatory connections deep within larval and adult brains. This technically facile approach can now be used in wild-type and mutant genetic backgrounds to address functional connectivity within neuronal networks governing a wide range of complex behaviors in the fly. Furthermore, the effectiveness of this approach in the fly brain suggests that similar methods using appropriate heterologous receptors might be adopted for other widely used model systems.
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