ArticleBiology of reproduction2012
Developmental programming: impact of prenatal testosterone excess on ovarian cell proliferation and apoptotic factors in sheep.
Article in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Evaluation of Anogenital Distance and Anti-Müllerian Hormone Plasmatic Concentration as Potential Phenotypes to Predict Reproductive Performance in Holstein Heifers.Veterinary sciences · 2024Article
- Transcriptome Analysis of Granulosa Cells Reveals Regulatory Mechanisms Related to Chicken Follicle Development.Animals : an open access journal from MDPI · 2023Article
- Prenatal Androgen Excess Induces Multigenerational Effects on Female and Male Descendants.Clinical medicine insights. Endocrinology and diabetes · 2023Article
- DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS.Epigenetics · 2020Article
- Developmental Programming: Sheep Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone.Endocrinology · 2020Article
- Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome.Endocrine reviews · 2020Review
- Developmental Programming: Prenatal Testosterone Excess on Ovarian SF1/DAX1/FOXO3.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Developmental Programming: Contribution of Epigenetic Enzymes to Antral Follicular Defects in the Sheep Model of PCOS.Endocrinology · 2019Article
- Ovarian and Extra-Ovarian Mediators in the Development of Polycystic Ovary Syndrome.Journal of molecular endocrinology · 2018Review
- Developmental Programming: Gestational Exposure to Excess Testosterone Alters Expression of Ovarian Matrix Metalloproteases and Their Target Proteins.Reproductive sciences (Thousand Oaks, Calif.) · 2018Article
- Developmental Programming of Ovarian Functions and Dysfunctions.Vitamins and hormones · 2018Review
- Ovarian follicular dynamics after aromatizable or non aromatizable neonatal androgenization.Journal of molecular histology · 2016Article
- Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption.Journal of ovarian research · 2016Article
- Article
- Steroidogenic versus Metabolic Programming of Reproductive Neuroendocrine, Ovarian and Metabolic Dysfunctions.Neuroendocrinology · 2015Review
- Patients with polycystic ovary syndrome have successful embryo arrest.International journal of clinical and experimental medicine · 2015Article
- Early dexamethasone treatment induces placental apoptosis in sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep.Endocrinology · 2014Article
- Reproduction Symposium: developmental programming of reproductive and metabolic health.Journal of animal science · 2014Review
- Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep.Reproductive sciences (Thousand Oaks, Calif.) · 2014Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Prenatal testosterone (T) excess leads to reproductive dysfunctions in sheep, which include increased ovarian follicular recruitment and persistence. To test the hypothesis that follicular disruptions in T sheep stem from changes in the developmental ontogeny of ovarian proliferation and apoptotic factors, pregnant Suffolk sheep were injected twice weekly with T propionate or dihydrotestosterone propionate (DHT; a nonaromatizable androgen) from Days 30 to 90 of gestation. Changes in developmental expression of proliferating cell nuclear antigen (PCNA), BCL2, BAX, activated CASP3, and FAS/FASLG were determined at Fetal Days 90 and 140, 22 wk, 10 mo, and 21 mo of age by immunocytochemisty. Prenatal T treatment induced changes in expression of proliferative and apoptotic markers in a follicle-, age-, and steroid-specific manner. Changes in BAX were evident only during fetal life and PCNA, BCL2, and CASP3 only postnatally. Prenatal T and not DHT increased PCNA and decreased BCL2 in granulosa/theca cells of antral follicles at 10 and 21 mo but decreased CASP3 in granulosa/theca cells of antral follicles at 22 wk (prepubertal) and 10 and 21 mo. Both treatments decreased BAX immunostaining in granulosa cells of Fetal Day 90 primordial/primary follicles. Neither treatment affected FAS expression at any developmental time point in any follicular compartment. Effects on BAX appear to be programmed by androgenic actions and PCNA, BCL2, and CASP3 by estrogenic actions of T. Overall, the findings demonstrate that fetal exposure to excess T disrupts the ovarian proliferation/apoptosis balance, thus providing a basis for the follicular disruptions evidenced in these females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.