Evidence map›Paper›PMID 22539654›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2012

Cognitive and physical functions as determinants of delayed age at onset and progression of disability.

Kumar B Rajan, Liesi E Hebert, Paul Scherr, Xinqi Dong, Robert S Wilson, Denis A Evans, Carlos F Mendes de Leon

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Article
  8. Article
  9. The relationship of longitudinal cognitive change to self-reported IADL in a general population.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2020
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  13. Motor Function Is Associated With Incident Disability in Older African Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016
    Observational
  14. Article
  15. Racial differences on association of depressive symptoms with combined basic and instrumental activities of daily living.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014
    Article
  16. The cognitive impairment of frail older persons.The journal of nutrition, health & aging · 2013
    Article
  17. Article
  18. Developing Occupation-Based Preventive Programs for Late-Middle-Aged Latino Patients in Safety-Net Health Systems.The American journal of occupational therapy : official publication of the American Occupational Therapy Association
    Article
  19. Trajectory of Mobility Decline by Type of Dementia.Alzheimer disease and associated disorders
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kumar B RajanRush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, 1645 W Jackson Blvd, Suite 675, Chicago, IL 60612, USA. kumar_rajan@rush.edu
Liesi E Hebert
Paul Scherr
Xinqi Dong
Robert S Wilson
Denis A Evans
Carlos F Mendes de Leon

Funding

Risk Factors for Incident Alzheimer's Disease in a Biracial CommunityR01AG011101 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI EVANS, DENIS A · 1993 to 2010
$24.7M
Early and Mid-Life Social Determinants of Racial Disparities in Late-Life HealthR01AG032247 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MENDES DE LEON, CARLOS F. · 2008 to 2011
$1.9M
NIA NIH HHS R01 AG011101NIA NIH HHS R01 AG032247NIA NIH HHS R01 AG11101
6 · The paper itself

Abstract

backgroundThis study examined the association of cognitive and physical functions with age-related transition and progression of activities of daily living (ADL) disability in a population-based longitudinal cohort of nondisabled older adults.

methodsA longitudinal population-based cohort study of 5,317 initially nondisabled older adults with an average age of 73.6 years of an urban Chicago community were interviewed annually for up to 8 years from 2000 through 2008. Cognitive function was assessed using a standardized global cognitive score and physical function using a combination of measured walk, tandem stand, and chair stand. A novel two-part model was used to access the relationship between cognitive and physical functions and age at onset and progression of ADL disability.

resultsThe sample consisted of 5,317 participants, 65% blacks, and 61% females. Twenty-five percent reported an onset of ADL disability during follow-up. After adjusting for confounders, lower cognitive and physical functions were associated with an increased risk for lower age at onset. Lower cognitive function was longitudinally associated with increased rate of progression of disability after onset. However, lower physical function did not alter the rate of progression of ADL disability.

conclusionsCognitive and physical functions were associated with age at onset. However, only cognitive function was associated with the rate of progression of ADL disability.

Indexed as

Activities of Daily LivingCognitionDisability EvaluationPersons with DisabilitiesAgedAged, 80 and overAge of OnsetCognition DisordersConfounding Factors, EpidemiologicDisease ProgressionFemaleGeriatric AssessmentHumansMale

Identifiers

PMID22539654
PMCPMC3636674

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.