ArticleNeurology2012
Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women.
Article in Neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- [Frequent neurological diseases associated with the restless legs syndrome].Der Nervenarzt · 2018Pooled it
- A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2015Pooled it
- Prevalence of restless legs syndrome in patients with multiple sclerosis, as confirmed by sleep disorders specialists.Journal of neurology · 2026Article
- Comorbidity and modifiable risk factors in multiple sclerosis.Therapeutic advances in neurological disorders · 2026Review
- Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran.BMC neurology · 2025Article
- Restless leg syndrome in multiple sclerosis: a case-control study.Frontiers in neurology · 2023Article
- Movement Disorders in Multiple Sclerosis: An Update.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022Review
- Sleep Problems in Chronic Inflammatory Diseases: Prevalence, Treatment, and New Perspectives: A Narrative Review.Journal of clinical medicine · 2021Review
- Therapeutic Approaches to Insomnia and Fatigue in Patients with Multiple Sclerosis.Nature and science of sleep · 2021Review
- Why Are Women Prone to Restless Legs Syndrome?International journal of environmental research and public health · 2020Review
- Physical activity, sedentary behavior, and restless legs syndrome in persons with multiple sclerosis.Journal of the neurological sciences · 2019Article
- Observational
- Overview: A Framework for the Discussion of Sleep in Multiple Sclerosis.Current sleep medicine reports · 2017Article
- Sleep disorders in patients with multiple sclerosis in China.Sleep & breathing = Schlaf & Atmung · 2017Article
- [Therapy of fatigue in multiple sclerosis : A treatment algorithm].Der Nervenarzt · 2016Review
- Sleep Disorders in Multiple Sclerosis.Current neurology and neuroscience reports · 2016Review
- The Berlin Treatment Algorithm: recommendations for tailored innovative therapeutic strategies for multiple sclerosis-related fatigue.The EPMA journal · 2016Review
- Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity.Sleep · 2016Article
- Restless leg syndrome and multiple sclerosis: a case-control study in China.Sleep & breathing = Schlaf & Atmung · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess the association of multiple sclerosis (MS) with concurrent restless legs syndrome (RLS) and daytime sleepiness. We also prospectively examined whether women with MS had an increased risk of developing RLS during 4 years of follow-up.
methodsThe main analysis was based on a cross-sectional study of 65,544 women (aged 41-58 years) free of diabetes, arthritis, and pregnancy, who were participating in the Nurses' Health Study II cohort. Participants were considered to have RLS if they met 4 RLS diagnostic criteria recommended by the International Restless Leg Syndrome Study Group and had restless legs ≥ 5 times/month. MS was self-reported and confirmed by medical record review.
resultsAmong women with MS, the prevalence of RLS and severe RLS (15+ times/month) were 15.5% and 9.9% in 2005, respectively, relative to 6.4% and 2.6% among women without MS. After adjustment for potential confounders and the presence of other sleep disorders, women with MS had a higher likelihood of having RLS (odds ratio [OR] = 2.72, 95% confidence interval [CI] 1.89-3.93), severe RLS (OR = 4.12, 95% CI 2.65-6.42), and daily daytime sleepiness (OR = 2.11, 95% CI 1.31-3.42) compared with women without MS. Among the 172 women who had MS and were free of RLS in 2005, 9 developed RLS (5.2%) during a 4-year period and all had severe RLS. The adjusted relative risk of severe RLS was 3.58 (95% CI 1.53-8.35), comparing women with MS at baseline with those without MS.
conclusionWomen with MS had a significantly higher prevalence of RLS and daytime sleepiness and an increased risk of developing RLS in the future.
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Registered trials
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