ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Foxg1 regulates the development of microvillous cells in the olfactory epithelium.Developmental biology · 2026Article
- Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos.iScience · 2025Article
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- The Olfactory Organ Is a Unique Site for Neutrophils in the Brain.Frontiers in immunology · 2022Article
- Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit.Nature communications · 2017Article
- Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons.Biology open · 2015Article
- GnRH, anosmia and hypogonadotropic hypogonadism--where are we?Frontiers in neuroendocrinology · 2015Review
- Olfactory sensory system develops from coordinated movements within the neural plate.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
- Establishing the pre-placodal region and breaking it into placodes with distinct identities.Developmental biology · 2014Review
- Neural crest and placode interaction during the development of the cranial sensory system.Developmental biology · 2014Review
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Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Vertebrate sensory organs originate from both cranial neural crest cells (CNCCs) and placodes. Previously, we have shown that the olfactory placode (OP) forms from a large field of cells extending caudally to the premigratory neural crest domain, and that OPs form through cell movements and not cell division. Concurrent with OP formation, CNCCs migrate rostrally to populate the frontal mass. However, little is known about the interactions between CNCCs and the placodes that form the olfactory sensory system. Previous reports suggest that the OP can generate cell types more typical of neural crest lineages such as neuroendocrine cells and glia, thus marking the OP as an unusual sensory placode. One possible explanation for this exception is that the neural crest origin of glia and neurons has been overlooked due to the intimate association of these two fields during migration. Using molecular markers and live imaging, we followed the development of OP precursors and of dorsally migrating CNCCs in zebrafish embryos. We generated a six4b:mCherry line (OP precursors) that, with a sox10:EGFP line (CNCCs), was used to follow cell migration. Our analyses showed that CNCCs associate with and eventually surround the forming OP with limited cell mixing occurring during this process.
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