Trial reportAnnals of biomedical engineering2012
Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.
Trial report in Annals of biomedical engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
96 citing papers in PubMed.
- Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients.Scientific reports · 2023Trial
- Effects of Pulsatile Flow on Fractional Flow Reserve Assessed Using a Reduced-Order Model.Annals of biomedical engineering · 2026Article
- Automated Tuning of Cardiovascular Boundary Conditions via Differentiable Surrogate Modeling.Annals of biomedical engineering · 2026Article
- Advancing Coronary Risk Assessment Through Combined Radiomic, Mechanical, and Hemodynamic Analysis.Annals of biomedical engineering · 2026Article
- An Automated Modular Platform for Vascular Graft Assessment via Coronary-like Flow-Induced Stimulation.Bioengineering (Basel, Switzerland) · 2026Article
- In Vitro Assessment of Coronary Perfusion after Valve-in-Valve Transcatheter Aortic Valve Implantation in a High-Risk Patient-Specific Experimental Model.Journal of cardiovascular translational research · 2026Article
- Computational Analysis of Disease Progression in Pediatric Pulmonary Arterial Hypertension.ArXiv · 2025Article
- Influence of boundary conditions and blood rheology on indices of wall shear stress from IVUS-based patient-specific stented coronary artery simulations.Scientific reports · 2025Article
- Hemodynamics of Proximal Coronary Lesions in Patients Undergoing Transcatheter Aortic Valve Implantation: Patient-Specific In Silico Study.Bioengineering (Basel, Switzerland) · 2025Article
- DIRECT MEDICAL IMAGE TO SIMULATION USING AUTO-SEGMENTATION AND POINT CLOUD-BASED CFD.Advances in computational science and engineering · 2025Article
- Hemodynamic Relevance Evaluation of Coronary Artery Anomaly During Stress Using FFR/IVUS in an Artificial Twin.JACC. Case reports · 2025Article
- Hybrid physics-based and data-driven modeling of vascular bifurcation pressure differences.Computers in biology and medicine · 2025Article
- Image-Based Computational Fluid Dynamics to Compare Two Repair Techniques for Mitral Valve Prolapse.Annals of biomedical engineering · 2024Article
- The Association Between the Hemodynamics in Anomalous Origins of Coronary Arteries and Atherosclerosis: A Preliminary Case Study Based on Computational Fluid Dynamics.Bioengineering (Basel, Switzerland) · 2024Article
- Efficient Cardiovascular Parameters Estimation for Fluid-Structure Simulations Using Gappy Proper Orthogonal Decomposition.Annals of biomedical engineering · 2024Article
- A preoperative planning procedure of septal myectomy for hypertrophic obstructive cardiomyopathy using image-based computational fluid dynamics simulations and shape optimization.Scientific reports · 2024Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- Surgical Modulation of Pulmonary Artery Shear Stress: A Patient-Specific CFD Analysis of the Norwood Procedure.Cardiovascular engineering and technology · 2024Article
- Hemodynamics and Wall Mechanics of Vascular Graft Failure.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Accelerated simulation methodologies for computational vascular flow modelling.Journal of the Royal Society, Interface · 2024Review
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
We present a computational framework for multiscale modeling and simulation of blood flow in coronary artery bypass graft (CABG) patients. Using this framework, only CT and non-invasive clinical measurements are required without the need to assume pressure and/or flow waveforms in the coronaries and we can capture global circulatory dynamics. We demonstrate this methodology in a case study of a patient with multiple CABGs. A patient-specific model of the blood vessels is constructed from CT image data to include the aorta, aortic branch vessels (brachiocephalic artery and carotids), the coronary arteries and multiple bypass grafts. The rest of the circulatory system is modeled using a lumped parameter network (LPN) 0 dimensional (0D) system comprised of resistances, capacitors (compliance), inductors (inertance), elastance and diodes (valves) that are tuned to match patient-specific clinical data. A finite element solver is used to compute blood flow and pressure in the 3D (3 dimensional) model, and this solver is implicitly coupled to the 0D LPN code at all inlets and outlets. By systematically parameterizing the graft geometry, we evaluate the influence of graft shape on the local hemodynamics, and global circulatory dynamics. Virtual manipulation of graft geometry is automated using Bezier splines and control points along the pathlines. Using this framework, we quantify wall shear stress, wall shear stress gradients and oscillatory shear index for different surgical geometries. We also compare pressures, flow rates and ventricular pressure-volume loops pre- and post-bypass graft surgery. We observe that PV loops do not change significantly after CABG but that both coronary perfusion and local hemodynamic parameters near the anastomosis region change substantially. Implications for future patient-specific optimization of CABG are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.