ArticleJapanese journal of ophthalmology2012
Infectious causes of posterior uveitis and panuveitis in Thailand.
Article in Japanese journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 21 citations in OpenAlex.
- Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.BMC ophthalmology · 2026Article
- Pattern of uveitis in a referral ophthalmology center in Northeastern Thailand.Journal of ophthalmic inflammation and infection · 2024Article
- Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis.Microorganisms · 2022Review
- Usefulness of aqueous and vitreous humor analysis in infectious uveitis.Clinics (Sao Paulo, Brazil) · 2020Article
- Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.BMC infectious diseases · 2019Article
- Comparison of the ocular characteristics of anterior uveitis caused by herpes simplex virus, varicella-zoster virus, and cytomegalovirus.Japanese journal of ophthalmology · 2014Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
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Abstract
purposeTo determine the infectious causes of posterior uveitis (PU) and panuveitis (panU) in Thailand.
methodsWe investigated the infectious causes of uveitis involving the posterior segment of the eye by using real-time polymerase chain reaction (PCR) for cytomegalovirus (CMV), herpes simplex virus (HSV-1, HSV-2), varicella zoster virus and Toxoplasma gondii (T. gondii) DNA in intraocular samples of 80 human immunodeficiency virus (HIV)-negative patients. Additionally, in 61 patients, we performed Goldmann-Witmer coefficient (GWC) analysis for T. gondii.
resultsTwenty-four (30 %) patients with PU and/or panU had a positive PCR result. Overall, CMV was the most frequently identified organism. While CMV was the most common cause of uveitis in the patients on immunosuppressive medications for nonocular disorders, HSV was the most common cause of posterior and panuveitis in the patients not receiving such medication. In 38 PU patients, CMV was the most common detected pathogen. In 42 panU patients, CMV and HSV-2 were the most frequently identified pathogens. Out of 61 paired samples analyzed for T. gondii by GWC analysis, only 1 revealed a positive result. There was no difference in PCR results between aqueous humor and vitreous samples.
conclusionsCMV was the most frequently identified infectious organism in posterior and panuveitis of HIV-1-negative Thai patients. Aqueous humor and vitreous samples showed similar diagnostic values in PCR analysis.
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