ArticleInternational journal of cancer2012
Prospective study of ultraviolet radiation exposure and risk of cancer in the United States.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 113 citations in OpenAlex.
- The Relationship Between Climate Change and Breast Cancer and Its Management and Preventative Implications in South Africa.International journal of environmental research and public health · 2025Pooled it
- Cumulative Erythemal Ultraviolet Radiation and Risk of Cancer in 3 Large US Prospective Cohorts.American journal of epidemiology · 2022Pooled it
- Sunlight exposure in association with risk of lymphoid malignancy: a meta-analysis of observational studies.Cancer causes & control : CCC · 2021Pooled it
- Vitamin D and Ovarian Cancer: Systematic Review of the Literature with a Focus on Molecular Mechanisms.Cells · 2020Pooled it
- Solar Ultraviolet Radiation and Breast Cancer Risk: A Systematic Review and Meta-Analysis.Environmental health perspectives · 2020Pooled it
- Pooled it
- UV-induced immune modulation in the lung niche slows cancer progression.Scientific reports · 2026Article
- Prospective pooled analyses of ambient ultraviolet radiation levels and risk of non-Hodgkin lymphoma and multiple myeloma.American journal of epidemiology · 2025Article
- A Comparative Study of Merkel Cell Carcinoma and Melanoma Incidence and Survival in the United States, 2000-2021.The Journal of investigative dermatology · 2025Article
- Alcohol Consumption and Melanoma in a Prospective United States Cohort Study: Results from the NIH-AARP Diet and Health Study.The Journal of nutrition · 2025Article
- Exposure-lag response of surface net solar radiation on lung cancer incidence: a global time-series analysis.Translational lung cancer research · 2024Article
- Ultraviolet and infrared radiation in Australia: assessing the benefits, risks, and optimal exposure guidelines.Frontiers in public health · 2024Review
- Moderate Low UVB Irradiation Modulates Tumor-associated Macrophages and Dendritic Cells and Promotes Antitumor Immunity in Tumor-bearing Mice.Photochemistry and photobiology · 2023Article
- Review
- Review
- Sun Exposure Is Associated with Reduced Breast Cancer Risk among Women Living in the Caribbean: The Atabey Study in Puerto Rico.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Residential ultraviolet radiation and breast cancer risk in a large prospective cohort.Environment international · 2022Article
- Environmental and social determinants of thyroid cancer: A spatial analysis based on the Geographical Detector.Frontiers in endocrinology · 2022Article
- Association between Citrus Consumption and Melanoma Risk in the NIH-AARP Diet and Health Study.Nutrition and cancer · 2021Article
- Associations between ultraviolet radiation, tree cover and adolescent sunburns.International journal of health geographics · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Ecologic studies have reported that solar ultraviolet radiation (UVR) exposure is associated with cancer; however, little evidence is available from prospective studies. We aimed to assess the association between an objective measure of ambient UVR exposure and risk of total and site-specific cancer in a large, regionally diverse cohort [450,934 white, non-Hispanic subjects (50-71 years) in the prospective National Institutes of Health (NIH)-AARP Diet and Health Study] after accounting for individual-level confounding risk factors. Estimated erythemal UVR exposure from satellite Total Ozone Mapping Spectrometer (TOMS) data from NASA was linked to the US Census Bureau 2000 census tract (centroid) of baseline residence for each subject. We used Cox proportional hazards models adjusted for multiple potential confounders to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for quartiles of UVR exposure. Restricted cubic splines examined nonlinear relationships. Over 9 years of follow-up, UVR exposure was inversely associated with total cancer risk (N = 75,917; highest versus lowest quartile; HR = 0.97, 95% CI = 0.95-0.99; p-trend < 0.001). In site-specific cancer analyses, UVR exposure was associated with increased melanoma risk (highest versus lowest quartile; HR = 1.22, 95% CI = 1.13-1.32; p-trend < 0.001) and decreased risk of non-Hodgkin's lymphoma (HR = 0.82, 95% CI = 0.74-0.92) and colon (HR = 0.88, 95% CI = 0.82-0.96), squamous cell lung (HR = 0.86, 95% CI = 0.75-0.98), pleural (HR = 0.57, 95% CI = 0.38-0.84), prostate (HR = 0.91, 95% CI = 0.88-0.95), kidney (HR = 0.83, 95% CI = 0.73-0.94) and bladder (HR = 0.88, 95% CI = 0.81-0.96) cancers (all p-trend < 0.05). We also found nonlinear associations for some cancer sites, including the thyroid and pancreas. Our results add to mounting evidence for the influential role of UVR exposure on cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.