ArticleLasers in medical science2013
Low-level laser therapy in different stages of rheumatoid arthritis: a histological study.
Article in Lasers in medical science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 72 citations in OpenAlex.
- Laser acupuncture versus reflexology therapy in elderly with rheumatoid arthritis.Lasers in medical science · 2017Trial
- The effect of low-level laser therapy on knee osteoarthritis: prospective, descriptive study.Lasers in medical science · 2014Trial
- Modulatory effects of photobiomodulation combined with resistance exercise on lymph node response during rheumatoid arthritis induction in Wistar rats.Einstein (Sao Paulo, Brazil) · 2026Article
- Low level laser therapy and rheumatoid arthritis: a systematic review and meta-analysis study.European journal of translational myology · 2024Article
- LED irradiation at 630 nm alleviates collagen-induced arthritis in mice by inhibition of NF-κB-mediated MMPs production.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review.International journal of molecular sciences · 2023Review
- Photobiomodulation for knee osteoarthritis: a model-based dosimetry study.Biomedical optics express · 2023Article
- Effects of low-level laser therapy and therapeutic ultrasound on Freund's complete adjuvant-induced knee arthritis model in rats.Archives of rheumatology · 2023Article
- High-frequency near-infrared diode laser irradiation suppresses IL-1β-induced inflammatory cytokine expression and NF-κB signaling pathways in human primary chondrocytes.Lasers in medical science · 2022Article
- Low-Level Laser Therapy for Rheumatoid Arthritis: A Review of Experimental Approaches.Journal of lasers in medical sciences · 2022Review
- Low-Level Laser Therapy in the Treatment of Autoimmune Thyroiditis.Journal of lasers in medical sciences · 2022Review
- Article
- Photobiomodulation with 630-nm LED radiation inhibits the proliferation of human synoviocyte MH7A cells possibly via TRPV4/PI3K/AKT/mTOR signaling pathway.Lasers in medical science · 2020Article
- Physical exercise and low-level laser therapy on the nociception and leukocyte migration of Wistar rats submitted to a model of rheumatoid arthritis.Lasers in medical science · 2020Article
- Photobiostimulation activity of different low-level laser dosage on masticatory muscles and temporomandibular joint in an induced arthritis rat model.Lasers in medical science · 2020Article
- Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model.Lasers in medical science · 2019Article
- Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.Current allergy and asthma reports · 2019Review
- Phototherapy suppresses inflammation in human nucleus pulposus cells for intervertebral disc degeneration.Lasers in medical science · 2018Article
- Low-intensity laser therapy efficacy evaluation in FVB mice subjected to acute and chronic arthritis.Lasers in medical science · 2017Article
- Cultured Human Fibroblast Biostimulation Using a 940 nm Diode Laser.Materials (Basel, Switzerland) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease of unknown etiology. Treatment of RA is very complex, and in the past years, some studies have investigated the use of low-level laser therapy (LLLT) in treatment of RA. However, it remains unknown if LLLT can modulate early and late stages of RA. With this perspective in mind, we evaluated histological aspects of LLLT effects in different RA progression stages in the knee. It was performed a collagen-induced RA model, and 20 male Wistar rats were divided into 4 experimental groups: a non-injured and non-treated control group, a RA non-treated group, a group treated with LLLT (780 nm, 22 mW, 0.10 W/cm(2), spot area of 0.214 cm(2), 7.7 J/cm(2), 75 s, 1.65 J per point, continuous mode) from 12th hour after collagen-induced RA, and a group treated with LLLT from 7th day after RA induction with same LLLT parameters. LLLT treatments were performed once per day. All animals were sacrificed at the 14th day from RA induction and articular tissue was collected in order to perform histological analyses related to inflammatory process. We observed that LLLT both at early and late RA progression stages significantly improved mononuclear inflammatory cells, exudate protein, medullary hemorrhage, hyperemia, necrosis, distribution of fibrocartilage, and chondroblasts and osteoblasts compared to RA group (p < 0.05). We can conclude that LLLT is able to modulate inflammatory response both in early as well as in late progression stages of RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.