ArticleProceedings of the National Academy of Sciences of the United States of America2012
Computational adaptive optics for broadband optical interferometric tomography of biological tissue.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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Who cites it
112 citing papers in PubMed, 217 citations in OpenAlex.
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- Dynamic full-field swept-source optical coherence tomography for high-resolution, long-depth, and intratissue-activity imaging.Biomedical optics express · 2026Article
- Dual deconvolution in multiphoton structured illumination microscopy for deep-tissue super-resolution imaging.Nature communications · 2026Article
- Computational aberration correction enables full-thickness retinal imaging with adaptive optics optical coherence tomography.Biocybernetics and biomedical engineering · 2026Article
- Quantum-inspired computational wavefront shaping enables turbulence-resilient distributed aperture synthesis imaging.Science advances · 2025Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- Image formation theory of optical coherence tomography with optical aberrations and its application to computational aberration correction.Biomedical optics express · 2025Article
- Large field-of-view volumetric deep brain imaging through gradient-index lenses.Nature communications · 2025Article
- Computational Adaptive Optics for HAR Hybrid Trench Array Topography Measurement by Utilizing Coherence Scanning Interferometry.Sensors (Basel, Switzerland) · 2025Article
- Computational approach for correcting defocus and suppressing speckle noise in line-field optical coherence tomography images.Biomedical optics express · 2024Article
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- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- Quantitative phase imaging techniques for measuring scattering properties of cells and tissues: a review-part II.Journal of biomedical optics · 2024Review
- K-Space Approach in Optical Coherence Tomography: Rigorous Digital Transformation of Arbitrary-Shape Beams, Aberration Elimination and Super-Refocusing beyond Conventional Phase Correction Procedures.Sensors (Basel, Switzerland) · 2024Article
- Computational wave-based photoacoustic imaging through an unknown thick aberrating layer.Photoacoustics · 2024Article
- Geometric transformation adaptive optics (GTAO) for volumetric deep brain imaging through gradient-index lenses.Nature communications · 2024Article
- Tandem aberration correction optics (TACO) in wide-field structured illumination microscopy.Biomedical optics express · 2023Article
52 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Aberrations in optical microscopy reduce image resolution and contrast, and can limit imaging depth when focusing into biological samples. Static correction of aberrations may be achieved through appropriate lens design, but this approach does not offer the flexibility of simultaneously correcting aberrations for all imaging depths, nor the adaptability to correct for sample-specific aberrations for high-quality tomographic optical imaging. Incorporation of adaptive optics (AO) methods have demonstrated considerable improvement in optical image contrast and resolution in noninterferometric microscopy techniques, as well as in optical coherence tomography. Here we present a method to correct aberrations in a tomogram rather than the beam of a broadband optical interferometry system. Based on Fourier optics principles, we correct aberrations of a virtual pupil using Zernike polynomials. When used in conjunction with the computed imaging method interferometric synthetic aperture microscopy, this computational AO enables object reconstruction (within the single scattering limit) with ideal focal-plane resolution at all depths. Tomographic reconstructions of tissue phantoms containing subresolution titanium-dioxide particles and of ex vivo rat lung tissue demonstrate aberration correction in datasets acquired with a highly astigmatic illumination beam. These results also demonstrate that imaging with an aberrated astigmatic beam provides the advantage of a more uniform depth-dependent signal compared to imaging with a standard gaussian beam. With further work, computational AO could enable the replacement of complicated and expensive optical hardware components with algorithms implemented on a standard desktop computer, making high-resolution 3D interferometric tomography accessible to a wider group of users and nonspecialists.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.