ArticleSurgical endoscopy2012
The LINX® reflux management system: confirmed safety and efficacy now at 4 years.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01058070 (An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter), which is not on this map. Cited by 49 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter
Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 132 citations in OpenAlex.
- MAGNETIC SPHINCTER AUGMENTATION DEVICE FOR GASTROESOPHAGEAL REFLUX DISEASE: EFFECTIVE, BUT POSTOPERATIVE DYSPHAGIA AND RISK OF EROSION SHOULD NOT BE UNDERESTIMATED. A SYSTEMATIC REVIEW AND META-ANALYSIS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2024Pooled it
- Systematic review of the introduction and evaluation of magnetic augmentation of the lower oesophageal sphincter for gastro-oesophageal reflux disease.The British journal of surgery · 2020Pooled it
- New treatment method for refractory gastroesophageal reflux disease (GERD): C-BLART (clip band ligation anti-reflux therapy)-a short-term study.Surgical endoscopy · 2020Trial
- Factors influencing the outcome of magnetic sphincter augmentation for chronic gastroesophageal reflux disease.Surgical endoscopy · 2018Trial
- Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler (MUSE™) for gastroesophageal reflux disease: 6-month results from a multi-center prospective trial.Surgical endoscopy · 2015Trial
- Patient-reported outcomes of laparoscopic magnetic sphincter augmentation for gastro-oesophageal reflux disease.Annals of the Royal College of Surgeons of England · 2024Article
- Removal of the magnetic sphincter augmentation device: an assessment of etiology, clinical presentation, and management.Surgical endoscopy · 2023Article
- The Evolving Use of Magnets in Surgery: Biomedical Considerations and a Review of Their Current Applications.Bioengineering (Basel, Switzerland) · 2023Review
- Safety profile of magnetic sphincter augmentation for gastroesophageal reflux disease.Frontiers in surgery · 2023Article
- Feasibility and Efficacy of Magnetic Sphincter Augmentation for the Management of Gastroesophageal Reflux Disease Post-Sleeve Gastrectomy for Obesity.Obesity surgery · 2023Observational
- Anti-reflux mucosectomy for refractory gastroesophageal reflux disease: a systematic review and meta-analysis.Endoscopy international open · 2022Review
- Evolution of a novel technology for gastroesophageal reflux disease: a safety perspective of magnetic sphincter augmentation.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Article
- Safety and efficacy of an implantable device for management of gastroesophageal reflux in lung transplant recipients.Journal of thoracic disease · 2021Article
- Gastroesophageal Reflux After Sleeve Gastrectomy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Review
- Transoral incisionless fundoplication demonstrates durability at up to 9 years.Therapeutic advances in gastroenterology · 2021Article
- A budget impact analysis of a magnetic sphincter augmentation device for the treatment of medication-refractory mechanical gastroesophageal reflux disease: a United States payer perspective.Surgical endoscopy · 2020Article
- LINXWorld journal of clinical cases · 2020Article
- Magnetic sphincter augmentation: Optimal patient selection and referral care pathways.World journal of gastrointestinal endoscopy · 2019Review
- Minimal versus obligatory dissection of the diaphragmatic hiatus during magnetic sphincter augmentation surgery.Surgical endoscopy · 2019Article
- Results of Magnetic Sphincter Augmentation for Gastroesophageal Reflux Disease.World journal of surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSphincter augmentation with the LINX® Reflux Management System is a surgical option for patients with chronic gastroesophageal disease (GERD) and an inadequate response to proton pump inhibitors (PPIs). Clinical experience with sphincter augmentation is now available out to 4 years.
methodsIn a multicenter, prospective, single-arm study, 44 patients underwent a laparoscopic surgical procedure for placement of the LINX System around the gastroesophageal junction (GEJ). Each patient's baseline GERD status served as the control for evaluations post implant. Long-term efficacy measures included esophageal acid exposure, GERD quality-of-life measures, and use of PPIs. Adverse events and long-term complications were closely monitored.
resultsFor esophageal acid exposure, the mean total % time pH < 4 was reduced from 11.9 % at baseline to 3.8 % at 3 years (p < 0.001), with 80 % (18/20) of patients achieving pH normalization (≤ 5.3 %). At ≥ 4 years, 100 % (23/23) of the patients had improved quality-of-life measures for GERD, and 80 % (20/25) had complete cessation of the use of PPIs. There have been no reports of death or long-term device-related complications such as migration or erosion.
conclusionsSphincter augmentation with the LINX Reflux Management System provided long-term clinical benefits with no safety issues, as demonstrated by reduced esophageal acid exposure, improved GERD-related quality of life, and cessation of dependence on PPIs, with minimal side effects and no safety issues. Patients with inadequate symptom control with acid suppression therapy may benefit from treatment with sphincter augmentation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.