ArticleJournal of microbiology (Seoul, Korea)2012
Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.
Article in Journal of microbiology (Seoul, Korea), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 112 citations in OpenAlex.
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- Efficacy of a Combined Natural Extract of Turmeric (Curcuma longa) and Liquorice (Glycyrrhiza uralensis) Against Viral Haemorrhagic Septicaemia Virus in Olive Flounders (Paralichthys olivaceus).Journal of fish diseases · 2026Article
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- Optimization of Ultrasonic-Assisted Extraction of Diene Urushiol from Lacquer Tree Leaves Using Response Surface Methodology.Molecules (Basel, Switzerland) · 2025Article
- Identification of novel potential inhibitors of monkeypox virus thymidine kinase using molecular docking, molecular dynamics simulation and MM/PBSA methods.Molecular diversity · 2024Article
- Investigation of phytochemicals isolated from selected Saudi medicinal plants as natural inhibitors of SARS CoV-2 main protease: In vitroSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Kaempferol is a novel antiviral agent against channel catfish virus infection through blocking viral attachment and penetrationFrontiers in veterinary science · 2023Article
- Exploring the roles of phytobiotics in relieving the impacts ofFrontiers in veterinary science · 2023Review
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- Review of Medicinal Plants and Active Pharmaceutical Ingredients against Aquatic Pathogenic Viruses.Viruses · 2022Review
- Novel anti-hepatitis B virus-active catechin and epicatechin fromExperimental and therapeutic medicine · 2022Article
- Phytocompounds as an Alternative Antimicrobial Approach in Aquaculture.Antibiotics (Basel, Switzerland) · 2022Review
- Effect of detoxifiedJournal of animal science and technology · 2022Article
- Antibacterial Activities of Prenylated Isoflavones fromMolecules (Basel, Switzerland) · 2021Article
- α-Lipoic Acid Exerts Its Antiviral Effect against Viral Hemorrhagic Septicemia Virus (VHSV) by Promoting Upregulation of Antiviral Genes and Suppressing VHSV-Induced Oxidative Stress.Virologica Sinica · 2021Article
- Sulfuretin exerts diversified functions in the processing of amyloid precursor protein.Genes & diseases · 2021Article
- De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity.Microbial biotechnology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An 80% methanolic extract of Rhus verniciflua Stokes bark showed significant anti-viral activity against fish pathogenic infectious hematopoietic necrosis virus (IHNV) and viral hemorrhagic septicemia virus (VHSV) in a cell-based assay measuring virus-induced cytopathic effect (CPE). Activity-guided fractionation and isolation for the 80% methanolic extract of R. verniciflua yielded the most active ethyl acetate fraction, and methyl gallate (1) and four flavonoids: fustin (2), fisetin (3), butin (4) and sulfuretin (5). Among them, fisetin (3) exhibited high antiviral activities against both IHNV and VHSV showing EC(50) values of 27.1 and 33.3 μM with selective indices (SI = CC(50)/EC(50)) more than 15, respectively. Fustin (2) and sulfuretin (5) displayed significant antiviral activities showing EC50 values of 91.2-197.3 μM against IHNV and VHSV. In addition, the antiviral activity of fisetin against IHNV and VHSV occurred up to 5 hr post-infection and was not associated with direct virucidal effects in a timed addition study using a plaque reduction assay. These results suggested that the bark of R. verniciflua and isolated flavonoids have significant anti-viral activity against IHNV and VHSV, and also have potential to be used as anti-viral therapeutics against fish viral diseases.
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