Evidence map›Paper›PMID 22538652›Full record

ArticleJournal of microbiology (Seoul, Korea)2012

Effects of exopolysaccharide production on liquid vegetative growth, stress survival, and stationary phase recovery in Myxococcus xanthus.

Wei Hu, Jing Wang, Ian McHardy, Renate Lux, Zhe Yang, Yuezhong Li, Wenyuan Shi

Abstract read
In one paragraph

Article in Journal of microbiology (Seoul, Korea), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wei HuSchool of Dentistry, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.
Jing Wang
Ian McHardy
Renate Lux
Zhe Yang
Yuezhong Li
Wenyuan Shi

Funding

INTERCELLULAR SIGNALING IN MYXOCOCCUS XANTHUSR01GM054666 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHI, WENYUAN · 1996 to 2010
$3.1M
NIGMS NIH HHS GM54666NIGMS NIH HHS R01 GM054666
6 · The paper itself

Abstract

Exopolysaccharide (EPS) of Myxococcus xanthus is a well-regulated cell surface component. In addition to its known functions for social motility and fruiting body formation on solid surfaces, EPS has also been proposed to play a role in multi-cellular clumping in liquid medium, though this phenomenon has not been well studied. In this report, we confirmed that M. xanthus clumps formed in liquid were correlated with EPS levels and demonstrated that the EPS encased cell clumps exhibited biofilm-like structures. The clumps protected the cells at physiologically relevant EPS concentrations, while cells lacking EPS exhibited significant reduction in long-term viability and resistance to stressful conditions. However, excess EPS production was counterproductive to vegetative growth and viable cell recovery declined in extended late stationary phase as cells became trapped in the matrix of clumps. Therefore, optimal EPS production by M. xanthus is important for normal physiological functions in liquid.

Indexed as

Culture MediaExtracellular SpaceMicrobial ViabilityMyxococcus xanthusPolysaccharides, BacterialCulture MediaPolysaccharides, Bacterial

Identifiers

PMID22538652
PMCPMC3819231

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.