ReviewJournal of neural transmission (Vienna, Austria : 1996)2012
Clock gene variants in mood and anxiety disorders.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 99 citations in OpenAlex.
- Unlocking Unique Physiological Reactions: Novel Insights into Four Cerebral and Systemic Physiological Responses to Colored Light.Advances in experimental medicine and biology · 2026Article
- A pancreas-hippocampus feedback mechanism regulates circadian changes in depression-related behaviors.Nature neuroscience · 2025Article
- Identification of a novel microdeletion at 9q21.13 in a family with epilepsy, intellectual disability, and speech disorders and literature review.Frontiers in genetics · 2025Article
- cNPAS2 induced β cell dysfunction by regulating KANK1 expression in type 2 diabetes.World journal of diabetes · 2024Article
- Article
- Machine learning analyses reveal circadian clock features predictive of anxiety among UK biobank participants.Scientific reports · 2023Article
- Review
- Effects of Positive Fighting Experience and Its Subsequent Deprivation on the Expression Profile of Mouse Hippocampal Genes Associated with Neurogenesis.International journal of molecular sciences · 2023Article
- The Genetic Side of the Mood: A Scientometric Review of the Genetic Basis of Mood Disorders.Genes · 2023Review
- Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation.Cannabis and cannabinoid research · 2022Article
- Machine learning and expression analyses reveal circadian clock features predictive of anxiety.Scientific reports · 2022Article
- Machine Learning Analyses Reveal Circadian Features Predictive of Risk for Sleep Disturbance.Nature and science of sleep · 2022Article
- The effects of circadian desynchronization on alcohol consumption and affective behavior during alcohol abstinence in female rats.Frontiers in behavioral neuroscience · 2022Article
- The molecular clock gene cryptochrome 1 (Cephalalgia : an international journal of headache · 2021Article
- Circadian disruption and human health.The Journal of clinical investigation · 2021Review
- Article
- Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.Neuroscience · 2021Review
- The darkness and the light: diurnal rodent models for seasonal affective disorder.Disease models & mechanisms · 2021Review
- Regulation of Circadian Genes by the MAPK Pathway: Implications for Rapid Antidepressant Action.Neuroscience bulletin · 2020Review
- Association analysis between chronic obstructive pulmonary disease and polymorphisms in circadian genes.PeerJ · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks are driven by signals from the habitat to match the solar day and to reset their phase relative to local time. A key function of the circadian clocks allows individuals to anticipate routine environmental conditions and to adjust their behaviors to the change of conditions. In clinical practice mood, anxiety and alcohol use disorders are often comorbid conditions. Clinical data have demonstrated that there are abnormalities in the circadian rhythms in patients with mood disorders and those with alcohol use disorders. Recent findings of molecular genetics have yielded the first insight into the targets of interest. Circadian clock gene variants are a fruitful target for elucidation of the pathogenesis. The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression. Concerning anxiety disorders and alcohol use disorders, the current findings are preliminary and need further verification to explain the association of ARNTL2, being suggestive only, with social phobia (rs2306073) and with alcohol abuse (rs7958822, rs4964057).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.