Evidence map›Paper›PMID 22538385›Full record

ReviewNeuropsychology review2012

Function and dysfunction of prefrontal brain circuitry in alcoholic Korsakoff's syndrome.

Marlene Oscar-Berman

Open access · greenAbstract readReview
In one paragraph

Review in Neuropsychology review, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 77 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. "Do not take that medication": negative prospective memory in Korsakoff's syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. The role of the orbitofrontal cortex in alcohol use, abuse, and dependence.Progress in neuro-psychopharmacology & biological psychiatry · 2018
    Review
  14. [Early onset substance abuse disorders and addictive diseases in old age].Zeitschrift fur Gerontologie und Geriatrie · 2018
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Marlene Oscar-BermanDepartment of Neurology and Division of Psychiatry, Boston University School of Medicine, Boston, MA, USA. oscar@bu.edu
Boston University · US

Funding

AFFECTIVE AND CONATIVE CHANGES IN ALCOHOLISMR01AA007112 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BERMAN, MARLENE OSCAR · 1987 to 2019
$8.3M
AFFECTIVE AND CONATIVE CHANGES IN ALCOHOLISMK05AA000219 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BERMAN, MARLENE OSCAR · 1997 to 2011
$1.8M
NIAAA NIH HHS K05 AA000219NIAAA NIH HHS K05-AA00219NIAAA NIH HHS R01 AA007112NIAAA NIH HHS R01-AA07112
6 · The paper itself

Abstract

The signature symptom of alcohol-induced persisting amnestic disorder, more commonly referred to as alcoholic Korsakoff's syndrome (KS), is anterograde amnesia, or memory loss for recent events, and until the mid 20th Century, the putative brain damage was considered to be in diencephalic and medial temporal lobe structures. Overall intelligence, as measured by standardized IQ tests, usually remains intact. Preservation of IQ occurs because memories formed before the onset of prolonged heavy drinking--the types of information and abilities tapped by intelligence tests--remain relatively well preserved compared with memories recently acquired. However, clinical and experimental evidence has shown that neurobehavioral dysfunction in alcoholic patients with KS does include nonmnemonic abilities, and further brain damage involves extensive frontal and limbic circuitries. Among the abnormalities are confabulation, disruption of elements of executive functioning and cognitive control, and emotional impairments. Here, we discuss the relationship between neurobehavioral impairments in KS and alcoholism-related brain damage. More specifically, we examine the role of damage to prefrontal brain systems in the neuropsychological profile of alcoholic KS.

Indexed as

Alcohol Amnestic DisorderBrainCognition DisordersEmotionsExecutive FunctionHumansNeural Pathways

Identifiers

PMID22538385
PMCPMC3681949
OpenAlexW2104445595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.