ArticleThe American journal of pathology2012
Immune modulation of vascular resident cells by Axl orchestrates carotid intima-media thickening.
Article in The American journal of pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- The interdependence of depressive symptoms and sleep in dyads affected by cancer.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Article
- Functions of TAM Receptors and Ligands Protein S and Gas6 in Atherosclerosis and Cardiovascular Disease.International journal of molecular sciences · 2024Review
- Growth Arrest Specific-6 and Axl Coordinate Inflammation and Hypertension.Circulation research · 2021Article
- Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.Communications biology · 2021Article
- Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Natriuretic Peptide Receptor 2 Locus Contributes to Carotid Remodeling.Journal of the American Heart Association · 2020Article
- The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.The American journal of pathology · 2019Article
- Strain-selective efficacy of sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains.British journal of pharmacology · 2019Article
- TAM receptors in cardiovascular disease.Cardiovascular research · 2019Review
- Axl expression is increased in early stages of left ventricular remodeling in an animal model with pressure-overload.PloS one · 2019Article
- Innate Immune Cells Are Regulated by Axl in Hypertensive Kidney.The American journal of pathology · 2018Article
- Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2018Article
- Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer.Oncogene · 2016Article
- Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- Axl modulates immune activation of smooth muscle cells in vein graft remodeling.American journal of physiology. Heart and circulatory physiology · 2015Article
- Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice.Journal of the American Heart Association · 2015Article
- Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function.The Journal of clinical investigation · 2015Article
- Axl as a mediator of cellular growth and survival.Oncotarget · 2014Review
- Role of Axl in early kidney inflammation and progression of salt-dependent hypertension.Hypertension (Dallas, Tex. : 1979) · 2013Article
- De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis.Circulation research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cellular mechanisms of carotid intima-media thickening (IMT) are largely unknown. The receptor tyrosine kinase Axl is essential for function of both bone marrow (BM) and non-BM cells. We studied the mechanisms by which Axl expression in BM-derived cells (compared with non-BM-derived cells) mediates carotid IMT. Partial ligation of the left carotid artery resulted in a similar carotid blood flow reduction in Axl chimeras. Neither irradiation nor bone marrow transplantation had any effect on the 40% difference in carotid IMT between Axl genotypes. Axl-dependent survival is very important for intimal leukocytes; however, Axl expression in BM cells contributes to <30% of carotid IMT. Axl in non-BM cells has a greater effect on carotid remodeling. Expression of Axl in non-BM cells is crucial for the up-regulation of several key proinflammatory signals (eg, IL-1) in the carotid. We found that Axl is involved in immune activation of cultured smooth muscle cells and in immune heterogeneity of medial cells (measured by major histocompatibility complex class II) after carotid injury. Finally, a lack of Axl in non-BM cells increased collagen Iα expression, which may play a critical role in carotid remodeling. Our data suggest that Axl contributes to carotid remodeling not only by inhibition of apoptosis but also via regulation of immune heterogeneity of vascular cells, cytokine/chemokine expression, and extracellular matrix remodeling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.