ReviewCurrent opinion in microbiology2012
Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology.
Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Amazonian Anopheles with low numbers of oocysts transmit Plasmodium vivax sporozoites during a blood meal.Scientific reports · 2022Article
- Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium.Scientific reports · 2022Article
- Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium.PLoS neglected tropical diseases · 2020Article
- Larval exposure to a pyrethroid insecticide and competition for food modulate the melanisation and antibacterial responses of adult Anopheles gambiae.Scientific reports · 2020Article
- Gene copy number and function of the APL1 immune factor changed during Anopheles evolution.Parasites & vectors · 2020Article
- Lipase is associated with deltamethrin resistance in Culex pipiens pallens.Parasitology research · 2020Article
- Disease vectors in the era of next generation sequencing.Genome biology · 2016Review
- An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors.PLoS pathogens · 2015Article
- Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa.Nature communications · 2015Article
- Venom allergen 5 is Associated With Deltamethrin Resistance in Culex pipiens pallens (Diptera: Culicidae).Journal of medical entomology · 2015Article
- Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes.Insects · 2015Review
- Antiviral immunity of Anopheles gambiae is highly compartmentalized, with distinct roles for RNA interference and gut microbiota.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Natural variation in virulence of the entomopathogenic fungus Beauveria bassiana against malaria mosquitoes.Malaria journal · 2014Article
- Blood feeding induces hemocyte proliferation and activation in the African malaria mosquito, Anopheles gambiae Giles.The Journal of experimental biology · 2014Article
- Next generation sequencing reveals regulation of distinct Aedes microRNAs during chikungunya virus development.PLoS neglected tropical diseases · 2014Article
- Nature, nurture and evolution of intra-species variation in mosquito arbovirus transmission competence.International journal of environmental research and public health · 2013Review
- Non-genetic determinants of mosquito competence for malaria parasites.PLoS pathogens · 2013Review
- Article
- Evidence for population-specific positive selection on immune genes of Anopheles gambiae.G3 (Bethesda, Md.) · 2012Article
- Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements.Pathogens and global healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Mosquitoes are the major arthropod vectors of human diseases such as malaria and viral encephalitis. However, each mosquito species does not transmit every pathogen, owing to reasons that include specific evolutionary histories, mosquito immune system structure, and ecology. Even a competent vector species for a pathogen displays a wide range of variation between individuals for pathogen susceptibility, and therefore efficiency of disease transmission. Understanding the molecular and genetic mechanisms that determine heterogeneities in transmission efficiency within a vector species could help elaborate new vector control strategies. This review discusses mechanisms of host-defense in Anopheles gambiae, and sources of genetic and ecological variation in the operation of these protective factors. Comparison is made between functional studies using Plasmodium or fungus, and we call attention to the limitations of generalizing gene phenotypes from experiments done in a single genetically simple colony.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.