ArticleGastroenterology2012
Consensus statements for management of Barrett's dysplasia and early-stage esophageal adenocarcinoma, based on a Delphi process.
Article in Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
134 citing papers in PubMed, 2 syntheses or guidelines pooled it, 377 citations in OpenAlex.
- Surgery versus radical endotherapies for early cancer and high-grade dysplasia in Barrett's oesophagus.The Cochrane database of systematic reviews · 2020Pooled it
- Glutathione S-transferase M1 null genotype contributes to increased risk of esophageal carcinoma in Chinese population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Radiofrequency ablation versus hybrid argon plasma coagulation in Barrett's esophagus: a prospective randomised trial.Surgical endoscopy · 2023Trial
- Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma.Journal of gastrointestinal cancer · 2022Trial
- Real-time diagnosis of Barrett's esophagus: a prospective, multicenter study comparing confocal laser endomicroscopy with conventional histology for the identification of intestinal metaplasia in new users.Surgical endoscopy · 2019Trial
- Trial
- Trial
- In vivo endomicroscopy improves detection of Barrett's esophagus-related neoplasia: a multicenter international randomized controlled trial (with video).Gastrointestinal endoscopy · 2014Trial
- Mucosal Versus Submucosal Lymphovascular Invasion in Early Esophageal Cancer.Annals of surgical oncology · 2026Article
- Establishing standards of care for forensic mental health: an international Delphi consensus-building study.Frontiers in psychiatry · 2026Article
- Modified Delphi Procedure to Achieve Consensus for the Concept of a National Curriculum for Minimally Invasive and Robot-assisted Surgery in Germany (GeRMIQ).Zentralblatt fur Chirurgie · 2025Article
- Microenvironment and Biomarkers in Esophageal Cancers: An Approach for Early Detection and Identification.Cureus · 2024Article
- Esophageal cancers missed at upper endoscopy in Central Norway 2004 to 2021 - A population-based study.BMC gastroenterology · 2024Article
- Evidence-based consensus guidelines for ALS genetic testing and counseling.Annals of clinical and translational neurology · 2023Article
- Integrating clinical access limitations into iPDT treatment planning with PDT-SPACE.Biomedical optics express · 2023Article
- Identifying a core symptom set triggering radiological and endoscopic investigations for suspected recurrent esophago-gastric cancer: a modified Delphi consensus process.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022Article
- Utilization trends for endoscopic ablation therapy and esophagectomy in Barrett's esophagus from 2005 to 2019.Scientific reports · 2022Observational
- Developing a Diagnostic Bundle for Bronchiectasis in South Korea: A Modified Delphi Consensus Study.Tuberculosis and respiratory diseases · 2022Article
- LAPAROSCOPIC ANTIREFLUX SURGERY: ARE OLD QUESTIONS ANSWERED? SHOULD IT BE USED CONJOINED WITH ENDOSCOPIC THERAPY FOR BARRETT'S ESOPHAGUS?Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Article
- Observational
74 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
92 authors at 20 institutions in 10 countries.
Funding
Abstract
BACKGROUND &
aimsEsophageal adenocarcinoma (EA) is increasingly common among patients with Barrett's esophagus (BE). We aimed to provide consensus recommendations based on the medical literature that clinicians could use to manage patients with BE and low-grade dysplasia, high-grade dysplasia (HGD), or early-stage EA.
methodsWe performed an international, multidisciplinary, systematic, evidence-based review of different management strategies for patients with BE and dysplasia or early-stage EA. We used a Delphi process to develop consensus statements. The results of literature searches were screened using a unique, interactive, Web-based data-sifting platform; we used 11,904 papers to inform the choice of statements selected. An a priori threshold of 80% agreement was used to establish consensus for each statement.
resultsEighty-one of the 91 statements achieved consensus despite generally low quality of evidence, including 8 clinical statements: (1) specimens from endoscopic resection are better than biopsies for staging lesions, (2) it is important to carefully map the size of the dysplastic areas, (3) patients that receive ablative or surgical therapy require endoscopic follow-up, (4) high-resolution endoscopy is necessary for accurate diagnosis, (5) endoscopic therapy for HGD is preferred to surveillance, (6) endoscopic therapy for HGD is preferred to surgery, (7) the combination of endoscopic resection and radiofrequency ablation is the most effective therapy, and (8) after endoscopic removal of lesions from patients with HGD, all areas of BE should be ablated.
conclusionsWe developed a data-sifting platform and used the Delphi process to create evidence-based consensus statements for the management of patients with BE and early-stage EA. This approach identified important clinical features of the diseases and areas for future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.