ArticleDevelopmental biology2012
β-Catenin stabilization in skeletal muscles, but not in motor neurons, leads to aberrant motor innervation of the muscle during neuromuscular development in mice.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Bltp1 Is Required for Survival and Normal Development and Function of the Neuromuscular Junction in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Crosstalk among canonical Wnt and Hippo pathway members in skeletal muscle and at the neuromuscular junction.Neural regeneration research · 2025Article
- The YAP1/TAZ-TEAD transcriptional network regulates gene expression at neuromuscular junctions in skeletal muscle fibers.Nucleic acids research · 2024Article
- The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction.Frontiers in molecular neuroscience · 2024Article
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- Synapse-specific Lrp4 mRNA enrichment requires Lrp4/MuSK signaling, muscle activity and Wnt non-canonical pathway.Cell & bioscience · 2021Article
- Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.PLoS genetics · 2019Article
- Dissecting the Extracellular Complexity of Neuromuscular Junction Organizers.Frontiers in molecular biosciences · 2019Review
- WNT/β-catenin signaling plays a crucial role in myoblast fusion through regulation of nephrin expression during development.Development (Cambridge, England) · 2018Article
- Article
- Evolution of the muscular system in tetrapod limbs.Zoological letters · 2018Review
- Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Schwann Cells in Neuromuscular Junction Formation and Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The role of Sema3-Npn-1 signaling during diaphragm innervation and muscle development.Journal of cell science · 2016Article
- R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5.Scientific reports · 2016Article
- Wt1 and β-catenin cooperatively regulate diaphragm development in the mouse.Developmental biology · 2015Article
- E-cadherin cytoplasmic domain inhibits cell surface localization of endogenous cadherins and fusion of C2C12 myoblasts.Biology open · 2015Article
- Slit2 as a β-catenin/Ctnnb1-dependent retrograde signal for presynaptic differentiation.eLife · 2015Article
- WNT/β-Catenin Signaling Regulates Multiple Steps of Myogenesis by Regulating Step-Specific Targets.Molecular and cellular biology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
β-Catenin, a key component of the Wnt signaling pathway, has been implicated in the development of the neuromuscular junction (NMJ) in mice, but its precise role in this process remains unclear. Here we use a β-catenin gain-of-function mouse model to stabilize β-catenin selectively in either skeletal muscles or motor neurons. We found that β-catenin stabilization in skeletal muscles resulted in increased motor axon number and excessive intramuscular nerve defasciculation and branching. In contrast, β-catenin stabilization in motor neurons had no adverse effect on motor innervation pattern. Furthermore, stabilization of β-catenin, either in skeletal muscles or in motor neurons, had no adverse effect on the formation and function of the NMJ. Our findings demonstrate that β-catenin levels in developing muscles in mice are crucial for proper muscle innervation, rather than specifically affecting synapse formation at the NMJ, and that the regulation of muscle innervation by β-catenin is mediated by a non-cell autonomous mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.