ArticleMolecular plant pathology2012
Identification of new Potato virus Y (PVY) molecular determinants for the induction of vein necrosis in tobacco.
Article in Molecular plant pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- A perillaldehyde-derived virucide targets phytoviral coat protein at Ser207 to impede intercellular spread.Pest management science · 2026Article
- Role of a Synonymous Mutation at Codon 178 in P1 That Attenuates Potato Virus Y-Induced Tobacco Vein Necrosis and Its Application for Expressing Human Interferon.Molecular plant pathology · 2026Article
- Development of an attenuated potato virus Y mutant carrying multiple mutations in helper-component protease for cross-protection.Virus research · 2024Article
- Innovative Arylimidazole-Fused Phytovirucides via Carbene-Catalyzed [3+4] Cycloaddition: Locking Viral Cell-To-Cell Movement by Out-Competing Virus Capsid-Host Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Disease-induced changes in bacterial and fungal communities from plant below- and aboveground compartments.Applied microbiology and biotechnology · 2024Article
- Potyviral Helper-Component Protease: Multifaced Functions and Interactions with Host Proteins.Plants (Basel, Switzerland) · 2024Review
- NIa-Pro of sugarcane mosaic virus targets Corn Cysteine Protease 1 (CCP1) to undermine salicylic acid-mediated defense in maize.PLoS pathogens · 2024Article
- A new point mutation in the HC-Pro of potato virus Y is involved in tobacco vein necrosis.PloS one · 2024Article
- Article
- Cas13d-mediated multiplex RNA targeting confers a broad-spectrum resistance against RNA viruses in potato.Communications biology · 2023Article
- The Mechanism of Resistance of EUROPEAN Plum toPlants (Basel, Switzerland) · 2023Article
- Next-generation sequencing identification and multiplex RT-PCR detection for viruses infecting cigar and flue-cured tobacco.Molecular biology reports · 2022Article
- Review
- The NIa-Protease Protein Encoded by theFrontiers in microbiology · 2020Article
- Generation of virus-resistant potato plants by RNA genome targeting.Plant biotechnology journal · 2019Article
- The HCPro from the Potyviridae family: an enviable multitasking Helper Component that every virus would like to have.Molecular plant pathology · 2018Review
- The 50 distal amino acids of the 2AMolecular plant pathology · 2018Article
- Hop/Sti1 - A Two-Faced Cochaperone Involved in Pattern Recognition Receptor Maturation and Viral Infection.Frontiers in plant science · 2017Article
- Recombination of strain O segments to HCpro-encoding sequence of strain N of Potato virus Y modulates necrosis induced in tobacco and in potatoes carrying resistance genes Ny or Nc.Molecular plant pathology · 2015Article
- Analysis of potato virus Y coat protein epitopes recognized by three commercial monoclonal antibodies.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two tobacco vein necrosis (TVN) determinants, the residues K(400) and E(419) , have been identified previously in the helper component-protease (HC-Pro) protein sequence of Potato virus Y (PVY). However, since their description, non-necrotic PVY isolates with both K(400) and E(419) necrotic determinants have been reported in the literature. This suggests the presence in the viral genome of other, as yet uncharacterized, TVN determinant(s). The identification of PVY(N) pathogenicity determinants was approached through the replacement of genomic regions of the necrotic PVY(N) -605 infectious clone by corresponding sequences from the non-necrotic PVY(O) -139 isolate. Series of PVY(N/O) chimeras and site-directed PVY mutants were constructed to test the involvement of different parts of the PVY genome (from nucleotide 421 to nucleotide 9629) in the induction of TVN symptoms. The analysis of both the genomic characteristics and biological properties of these mutants made it possible to highlight the involvement, in addition to residues K(400) and E(419), of the residue N(339) of the HC-Pro protein and two regions in the cytoplasmic inclusion (CI) protein to nuclear inclusion protein a-protease (NIa-Pro) sequence (nucleotides 5496-5932 and 6233-6444) in the induction of vein necrosis in tobacco infected by PVY isolates.
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