Trial reportCongestive heart failure (Greenwich, Conn.)
Exercise training improves heart rate variability in older patients with heart failure: a randomized, controlled, single-blinded trial.
Trial report in Congestive heart failure (Greenwich, Conn.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Effects of Exercise on Autonomic Cardiovascular Function in Older Adults: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Heart Rate Variability and Heart Failure with Reduced Ejection Fraction: A Systematic Review of Literature.Current cardiology reviews · 2025Pooled it
- Beneficial impacts of physical activity on heart rate variability: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Effects of resistance added on aerobic training on autonomic function in cardiac patients.Anatolian journal of cardiology · 2022Pooled it
- Effects of exercise training in heart failure with preserved ejection fraction: an updated systematic literature review.Heart failure reviews · 2020Pooled it
- Exercise therapy and autonomic function in heart failure patients: a systematic review and meta-analysis.Heart failure reviews · 2018Pooled it
- Effects of Exercise Training on Autonomic Function in Chronic Heart Failure: Systematic Review.BioMed research international · 2015Pooled it
- Can high-intensity interval training change cardiac autonomic control? A systematic review.Brazilian journal of physical therapyPooled it
- The Acute Effects of 2 Different Intensities of Resistance Exercise on Autonomic Function in Heart Failure Patients: A Randomized Controlled Trial.Anatolian journal of cardiology · 2023Trial
- Cardiovascular autonomic modulation differences between moderate-intensity continuous and high-intensity interval aerobic training in women with PCOS: A randomized trial.Frontiers in endocrinology · 2022Trial
- Impact of an exercise training program on cardiac neuronal function in heart failure patients on optimal medical therapy : A randomized Iodine-123 metaiodobenzylguanidine scintigraphy study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
- Positive Effects of the Reversion of Depression on the Sympathovagal Balance after Telerehabilitation in Heart Failure Patients.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2016Trial
- Trial
- Heart Rate Variability Is Associated with Exercise Capacity in Patients with Cardiac Syndrome X.PloS one · 2016Trial
- Effects of exercise training on heart rate variability in Chagas heart disease.Arquivos brasileiros de cardiologia · 2014Trial
- Practical guidelines for exercise prescription in different clinical populations.Frontiers in sports and active living · 2026Review
- Non-Invasive Wearable Technology to Predict Heart Failure Decompensation.Journal of clinical medicine · 2025Review
- State Space Correspondence and Cross-Entropy Methods in the Assessment of Bidirectional Cardiorespiratory Coupling in Heart Failure.Entropy (Basel, Switzerland) · 2025Article
- Exercise Training in Heart Failure: Clinical Benefits and Mechanisms.Circulation research · 2025Review
- Heart Rate Variability Analysis in Congestive Heart Failure: The Need for Standardized Assessment Protocols.Reviews in cardiovascular medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Reduced heart rate variability (HRV) in older patients with heart failure (HF) is common and indicates poor prognosis. Exercise training (ET) has been shown to improve HRV in younger patients with HF. However, the effect of ET on HRV in older patients with HF is not known. Sixty-six participants (36% men), aged 69±5 years, with HF and both preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF), were randomly assigned to 16 weeks of supervised ET (ET group) vs attention-control (AC group). Two HRV parameters (the standard deviation of all normal RR intervals [SDNN] and the root mean square of successive differences in normal RR intervals [RMSSD]) were measured at baseline and after completion of the study. When compared with the AC group, the ET group had a significantly greater increase in both SDNN (15.46±5.02 ms in ET vs 2.37±2.13 ms in AC, P=.016) and RMSSD (17.53±7.83 ms in ET vs 1.69±2.63 ms in AC, P=.003). This increase was seen in both sexes and HF categories. ET improved HRV in older patients with both HFREF and HFPEF.
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Registered trials
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