ReviewActa paediatrica (Oslo, Norway : 1992)2012
Unexpected extra-renal effects of loop diuretics in the preterm neonate.
Review in Acta paediatrica (Oslo, Norway : 1992), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- What is the role of diuretics in the prevention and management of bronchopulmonary dysplasia?Current treatment options in pediatrics · 2026Article
- Patent Ductus Arteriosus in Extremely Preterm Infants: Update on Current Diagnostic and Treatment Options.Current treatment options in cardiovascular medicine · 2025Review
- Diuretic Tolerance to Repeated-Dose Furosemide in Infants Born Very Preterm with Bronchopulmonary Dysplasia.The Journal of pediatrics · 2024Article
- Weaning and extubation from neonatal mechanical ventilation: an evidenced-based review.BMC pulmonary medicine · 2022Review
- Article
- A whole blood microsampling furosemide assay: development, validation and use in a pediatric pharmacokinetic study.Bioanalysis · 2022Article
- Development, validation, and implementation of an UHPLC-MS/MS method for the quantitation of furosemide in infant urine samples.Biomedical chromatography : BMC · 2022Article
- Optimizing respiratory management in preterm infants: a review of adjuvant pharmacotherapies.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment.Seminars in fetal & neonatal medicine · 2018Review
- Diagnosis and Management of Patent Ductus Arteriosus.NeoReviews · 2018Article
- Furosemide diminishes ¹⁸F-fluoroethylcholine uptake in prostate cancer in vivo.European journal of nuclear medicine and molecular imaging · 2014Article
- Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA.American journal of physiology. Heart and circulatory physiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledThe loop diuretics furosemide and bumetanide are commonly used in neonatal intensive care units (NICUs). Furosemide, because of its actions on the ubiquitous Na(+) -K(+) -2Cl(-) isoform cotransporter and its promotion of prostanoid production and release, also has non-diuretic effects on vascular smooth muscle, airways, the ductus arteriosus and theoretically the gastrointestinal tract. Loop diuretics also affect the central nervous system through modulation of the GABA-A chloride channel.
conclusionThe loop diuretics have a variety of biological effects that are potentially harmful as well as beneficial. Care should be taken with the use of these agents because the range of their effects may be broader than the single action sought by the prescribing physician.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.