ArticleVeterinary research2012
Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation.
Article in Veterinary research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- ExperimentalFrontiers in veterinary science · 2022Review
- Are infectious reproductive pathogens of large ruminants a threat to improving food security? An investigation from Cambodia.Tropical animal health and production · 2021Article
- Maternal and Foetal Cellular Immune Responses in Dams Infected With High- and Low- Virulence Isolates ofFrontiers in cellular and infection microbiology · 2021Article
- Effects of challenge dose and inoculation route of the virulent Neospora caninum Nc-Spain7 isolate in pregnant cattle at mid-gestation.Veterinary research · 2019Article
- Article
- Influence of dose and route of administration on the outcome of infection with the virulent Neospora caninum isolate Nc-Spain7 in pregnant sheep at mid-gestation.Veterinary research · 2018Article
- Neospora caninum infection during early pregnancy in cattle: how the isolate influences infection dynamics, clinical outcome and peripheral and local immune responses.Veterinary research · 2014Article
- Development of maternal and foetal immune responses in cattle following experimental challenge with Neospora caninum at day 210 of gestation.Veterinary research · 2013Article
- Mucosal and systemic T cell response in mice intragastrically infected with Neospora caninum tachyzoites.Veterinary research · 2013Article
- Phenotypic characterisation of the cellular immune infiltrate in placentas of cattle following experimental inoculation with Neospora caninum in late gestation.Veterinary research · 2013Article
- Tissue distribution of Neospora caninum in experimentally infected cattle.Clinical and vaccine immunology : CVI · 2013Article
- High rate of transplacental infection and transmission of Neospora caninum following experimental challenge of cattle at day 210 of gestation.Veterinary research · 2012Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune responses of pregnant cattle and their foetuses were examined following inoculation on day 70 of gestation either intravenously (iv) (group 1) or subcutaneously (sc) (group 2) with live NC1 strain tachyzoites or with Vero cells (control) (group 3). Peripheral blood mononuclear cell (PBMC) responses to Neospora antigen and foetal viability were assessed throughout the experiment. Two animals from each group were sacrificed at 14, 28, 42 and 56 days post inoculation (pi). At post mortem, maternal lymph nodes, spleen and PBMC and when possible foetal spleen, thymus and PBMC samples were collected for analysis. Inoculation with NC1 (iv and sc) lead to foetal deaths in all group 1 dams (6/6) and in 3/6 group 2 dams from day 28pi; statistically significant (p ≤ 0.05) increases in cell-mediated immune (CMI) responses including antigen-specific cell proliferation and IFN-γ production as well as increased levels of IL-4, IL-10 and IL-12 were observed in challenged dams compared to the group 3 animals. Lymph node samples from the group 2 animals carrying live foetuses showed greater levels of cellular proliferation as well as significantly (p ≤ 0.05) higher levels of IFN-γ compared to the dams in group 2 carrying dead foetuses. Foetal spleen, thymus and PBMC samples demonstrated cellular proliferation as well as IFN-γ, IL-4, IL-10 and IL-12 production following mitogenic stimulation with Con A from day 14pi (day 84 gestation) onwards. This study shows that the generation of robust peripheral and local maternal CMI responses (lymphoproliferation, IFN-γ) may inhibit the vertical transmission of the parasite.
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