Evidence map›Paper›PMID 22536753›Full record

ArticleClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2012

Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.

M Colafigli, C Torti, E M Trecarichi, L Albini, A Rosi, V Micheli, N Manca, G Penco, B Bruzzone, G Punzi and 8 more

Abstract read
In one paragraph

Article in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. National molecular surveillance of recently acquired HIV infections in Germany, 2013 to 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Aging with HIV: a practical review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

M ColafigliInstitute of Clinical Infectious Diseases, Catholic University of S. Heart, Rome, Italy. manuela76@inwind.it
C Torti
E M Trecarichi
L Albini
A Rosi
V Micheli
N Manca
G Penco
B Bruzzone
G Punzi
P Corsi
G Parruti
P Bagnarelli
L Monno
A Gonnelli
R Cauda
S Di Giambenedetto
ARCA, UCSC and Brescia HIV resistance study groups

Funding

Viral evolution in peropheral macrophages and brain during progression to AIDSR01NS063897 · NINDS · UNIVERSITY OF FLORIDA · PI SALEMI, MARCO · 2009 to 2021
$7.0M
NINDS NIH HHS NS063897-01A2NINDS NIH HHS R01 NS063897
6 · The paper itself

Abstract

Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.

Indexed as

Drug Resistance, ViralEvolution, MolecularAdultAnti-HIV AgentsFemaleGenotypeHIV-1HIV InfectionsHumansItalyMaleMiddle AgedPrevalenceAnti-HIV Agents

Identifiers

PMID22536753
PMCPMC6029625

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.