ArticleAnatomy & cell biology2012
Expression and roles of NUPR1 in cholangiocarcinoma cells.
Article in Anatomy & cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Silencing serine/arginine-rich splicing factor 1 to induce apoptosis and autophagy-dependent cell death in cholangiocarcinoma through the correction of oncogenic splicing errors.Anatomy & cell biology · 2025Article
- ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma.Discover oncology · 2024Article
- NUPR1 protects against hyperPARylation-dependent cell death.Communications biology · 2022Article
- Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function.Biomolecules · 2021Article
- NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner.Cell death discovery · 2021Article
- NUPR1: A Critical Regulator of the Antioxidant System.Cancers · 2021Review
- ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.JCI insight · 2020Article
- Targeting intrinsically disordered proteins involved in cancer.Cellular and molecular life sciences : CMLS · 2020Review
- Review
- Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.The Journal of clinical investigation · 2019Article
- Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.Scientific reports · 2018Article
- Article
- Depletion of C3orf1/TIMMDC1 inhibits migration and proliferation in 95D lung carcinoma cells.International journal of molecular sciences · 2014Article
- WTAP regulates migration and invasion of cholangiocarcinoma cells.Journal of gastroenterology · 2013Article
- In vitro neuraotropic growth of cholangiocarcinoma: an experimental study.JRSM short reports · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.