ArticlePloS one2012
Lineages, sub-lineages and variants of enterovirus 68 in recent outbreaks.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis.PLoS neglected tropical diseases · 2022Pooled it
- Enterovirus D68 B3 clade strains are efficiently recovered from cDNA infectious clones in 293T cells and infect human spinal cord organoids.Journal of virology · 2026Article
- Frequent detection of enterovirus D68 and rhinovirus type C in children with acute respiratory infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Acute Flaccid Myelitis: Current Status and Diagnostic Challenges.Journal of clinical neurology (Seoul, Korea) · 2020Review
- Review
- Association of Enterovirus D68 with Acute Flaccid Myelitis, Philadelphia, Pennsylvania, USA, 2009-2018.Emerging infectious diseases · 2019Article
- Enterovirus D68 and other enterovirus serotypes identified in South African patients with severe acute respiratory illness, 2009-2011.Influenza and other respiratory viruses · 2017Article
- Respiratory infections associated with enterovirus D68 from 2011 to 2015 in Beijing, China.Journal of medical virology · 2016Article
- Enterovirus D68 and Human Respiratory Infections.Seminars in respiratory and critical care medicine · 2016Review
- Molecular Evolution and Intraclade Recombination of Enterovirus D68 during the 2014 Outbreak in the United States.Journal of virology · 2016Article
- Enterovirus D68 receptor requirements unveiled by haploid genetics.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Enterovirus D-68 Infection, Prophylaxis, and Vaccination in a Novel Permissive Animal Model, the Cotton Rat (Sigmodon hispidus).PloS one · 2016Article
- Prevalence and molecular characterizations of enterovirus D68 among children with acute respiratory infection in China between 2012 and 2014.Scientific reports · 2015Article
- Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation.The Lancet. Respiratory medicine · 2015Article
- Low-level Circulation of Enterovirus D68-Associated Acute Respiratory Infections, Germany, 2014.Emerging infectious diseases · 2015Article
- Detection of enterovirus D68 in Canadian laboratories.Journal of clinical microbiology · 2015Article
- Global reemergence of enterovirus D68 as an important pathogen for acute respiratory infections.Reviews in medical virology · 2015Review
- Analysis of Enterovirus 68 Strains from the 2014 North American Outbreak Reveals a New Clade, Indicating Viral Evolution.PloS one · 2015Article
- A child with acute encephalopathy associated with quadruple viral infection.Frontiers in pediatrics · 2015Article
- Epidemic 2014 enterovirus D68 cross-reacts with human rhinovirus on a respiratory molecular diagnostic platform.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterovirus 68 (EV68) was first isolated in 1962. Very few cases of EV68 infection were described over the ensuing 40 years. However, in the past few years, an increase in severe respiratory tract infections associated with EV68 has been reported. We identified two clusters of EV68 infection in South London, UK, one each in the autumn/winters of 2009 and 2010. Sequence comparison showed significant homology of the UK strains with those from other countries including the Netherlands, Japan and the Philippines, which reported EV68 outbreaks between 2008 and 2010. Phylogenetic analysis of all available VP1 sequences indicated the presence of two modern EV68 lineages. The 2010 UK strains belonged to lineage 2. Lineage 1 could be further divided into two sub-lineages: some Japanese and Dutch strains collected between 2004 and 2010 form a distinct sub-lineages (sub-lineage 1.1), whereas other strains from the UK, Japan, Netherlands and Philippines collected between 2008 and 2010 represent sub-lineage 1.2. The UK 2009 strains together with several Dutch and Japanese strains from 2009/2010 represents one variant (1.2.1), whereas those from the Philippines a second variant (1.2.2). Based on specific deletions and substitutions, we suggest rules for the assignment of lineages and sub-lineages. Molecular epidemiological analysis indicates rapid recent evolution of EV68 and this may explain the recent findings of a global resurgence of EV68. Continuous global monitoring of the clinical and molecular epidemiology of EV68 is recommended.
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