ArticlePloS one2012
New insights into the evolution of metazoan tyrosinase gene family.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Abalone genomics reveals an ancient asymmetry axis and the multifunctionality of the mantle.Science advances · 2026Article
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- Diversity and evolution of tyrosinase enzymes involved in the adhesive systems of mussels and tubeworms.iScience · 2024Article
- Structural and Evolutionary Relationships of Melanin Cascade Proteins in Cnidarian Innate Immunity.Integrative and comparative biology · 2024Article
- Coloration in Equine: Overview of Candidate Genes Associated with Coat Color Phenotypes.Animals : an open access journal from MDPI · 2024Review
- Single cell atlas of Xenoturbella bocki highlights limited cell-type complexity.Nature communications · 2024Article
- The biochemistry of melanogenesis: an insight into the function and mechanism of melanogenesis-related proteins.Frontiers in molecular biosciences · 2024Review
- Phenoloxidases: catechol oxidase - the temporary employer and laccase - the rising star of vascular plants.Horticulture research · 2023Article
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- Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans.Current biology : CB · 2022Article
- Zebrafish Syndromic Albinism Models as Tools for Understanding and Treating Pigment Cell Disease in Humans.Cancers · 2022Review
- Light modulated cnidocyte discharge predates the origins of eyes in Cnidaria.Ecology and evolution · 2021Article
- Review
- Brain Sensory Organs of the AscidianFrontiers in cell and developmental biology · 2021Review
- Phenoloxidases in Plants-How Structural Diversity Enables Functional Specificity.Frontiers in plant science · 2021Review
- Melanin production byBiotechnologia · 2021Article
- Review
- TheFrontiers in cell and developmental biology · 2020Article
- Evolutionary loss of melanogenesis in the tunicateEvoDevo · 2017Article
- An Antarctic molluscan biomineralisation tool-kit.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tyrosinases, widely distributed among animals, plants and fungi, are involved in the biosynthesis of melanin, a pigment that has been exploited, in the course of evolution, to serve different functions. We conducted a deep evolutionary analysis of tyrosinase family amongst metazoa, thanks to the availability of new sequenced genomes, assessing that tyrosinases (tyr) represent a distinctive feature of all the organisms included in our study and, interestingly, they show an independent expansion in most of the analyzed phyla. Tyrosinase-related proteins (tyrp), which derive from tyr but show distinct key residues in the catalytic domain, constitute an invention of chordate lineage. In addition we here reported a detailed study of the expression territories of the ascidian Ciona intestinalis tyr and tyrps. Furthermore, we put efforts in the identification of the regulatory sequences responsible for their expression in pigment cell lineage. Collectively, the results reported here enlarge our knowledge about the tyrosinase gene family as valuable resource for understanding the genetic components involved in pigment cells evolution and development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.