ReviewDeutsches Arzteblatt international2012
Treatment algorithms for chronic osteomyelitis.
Review in Deutsches Arzteblatt international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05467644 (Treatment of Fracture Related Infection in Latin America. International Multicenter Study), which is not on this map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Fracture Related Infection in Latin America. International Multicenter Study
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it, 221 citations in OpenAlex.
- A systematic review of the single-stage treatment of chronic osteomyelitis.Journal of orthopaedic surgery and research · 2019Pooled it
- Antibiotics for treating chronic osteomyelitis in adults.The Cochrane database of systematic reviews · 2013Pooled it
- Recommendations for the treatment of osteomyelitis.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesGuideline
- Evaluating chronic bone and soft tissue infections with [European journal of nuclear medicine and molecular imaging · 2026Article
- Berberine alleviates biofilm-associated immune-inflammatory injury inFrontiers in immunology · 2026Article
- Combination of single-cell and bulk RNA-seq reveals changes in the immune landscape in osteomyelitis.Frontiers in immunology · 2026Article
- Early postoperative C-reactive protein-to-albumin ratio for risk stratification of osteomyelitis recurrence after surgical treatment.Frontiers in medicine · 2026Article
- Coaxial electrospun fibers for control release of vancomycin and diclofenac in osteomyelitis management.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Article
- Biomaterial-mediated macrophage polarization remodeling and sequential regulation: a potential strategy in bone infections treatment.Bone research · 2025Review
- Genetically predicted immune cell mediate the association between plasma lipidomics and osteomyelitis.European journal of medical research · 2025Article
- A comprehensive review of pathology and treatment of staphylococcus aureus osteomyelitis.Clinical and experimental medicine · 2025Review
- Vancomycin-Loaded Silk Fibroin/Calcium Phosphate/Methylcellulose-Based In Situ Thermosensitive Hydrogel: A Potential Function for Bone Regeneration.Gels (Basel, Switzerland) · 2024Article
- The Use of Dissolvable Synthetic Calcium Impregnated with Antibiotic in Osteoarticular Infection in Patients with Diabetes.Life (Basel, Switzerland) · 2024Article
- Uncovering lipid dynamics in Staphylococcus aureus osteomyelitis using multimodal imaging mass spectrometry.Cell chemical biology · 2024Article
- Ilizarov External Fixator Versus Orthofix LRS in Management of Femoral Osteomyelitis: A Propensity Score Matched Analysis.Indian journal of orthopaedics · 2024Article
- Integrative gene expression analysis and animal model reveal immune- and autophagy-related biomarkers in osteomyelitis.Immunity, inflammation and disease · 2024Article
- Recurrent skin opening induced by chronic sternal osteomyelitis caused by a bite wound in a cat: A case report.Veterinary medicine and science · 2024Article
- Clinical outcomes and complications of S53P4 bioactive glass in chronic osteomyelitis and septic non-unions: a retrospective single-center study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- [Diagnostic and therapeutic work-up of infected tibial nonunion].Unfallchirurgie (Heidelberg, Germany) · 2024Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteomyelitis was described many years ago but is still incompletely understood. Its exogenously acquired form is likely to become more common as the population ages. We discuss biofilm formation as a clinically relevant pathophysiological model and present current recommendations for the treatment of osteomyelitis.
methodsWe selectively searched the PubMed and Cochrane databases for articles on the treatment of chronic osteomyelitis with local and systemic antibiotics and with surgery. The biofilm hypothesis is discussed in the light of the current literature.
resultsThere is still no consensus on either the definition of osteomyelitis or the criteria for its diagnosis. Most of the published studies cannot be compared with one another, and there is a lack of scientific evidence to guide treatment. The therapeutic recommendations are, therefore, based on the findings of individual studies and on current textbooks. There are two approaches to treatment, with either curative or palliative intent; surgery is now the most important treatment modality in both. In addition to surgery, antibiotics must also be given, with the choice of agent determined by the sensitivity spectrum of the pathogen.
conclusionSurgery combined with anti-infective chemotherapy leads to long-lasting containment of infection in 70% to 90% of cases. Suitable drugs are not yet available for the eradication of biofilm-producing bacteria.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.