ArticleEvidence-based complementary and alternative medicine : eCAM2012
A Study of the Wound Healing Mechanism of a Traditional Chinese Medicine, Angelica sinensis, Using a Proteomic Approach.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Therapeutic Effects of Medicinal Plants on Cutaneous Wound Healing in Humans: A Systematic Review.Mediators of inflammation · 2018Pooled it
- Activity ofFrontiers in pharmacology · 2026Article
- Use of Medicinal Plants in the Process of Wound Healing: A Literature Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- SNHG12/NFYC-AS1 Acted as the Sponge for hsa-miR-199a-5p to Promote the Expression of S100A8/S100A7/XDH and was Involved in the Progression of Diabetic Foot Ulcers.Molecular biotechnology · 2023Article
- Kampo herbal ointments for skin wound healing.Frontiers in pharmacology · 2023Review
- A Lead Target Molecule for Excisional Wound Healing: Trypthantrin Compound.Iranian journal of pharmaceutical research : IJPR · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Promotive effects of four herbal medicine ARCC on wound healing in mice and human.Health science reports · 2022Article
- Recent Advances in Nanozymes for Bacteria-Infected Wound Therapy.International journal of nanomedicine · 2022Review
- An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis.Frontiers in pharmacology · 2022Review
- Botanical Drugs in Traditional Chinese Medicine With Wound Healing Properties.Frontiers in pharmacology · 2022Review
- Ethnobotanical Survey on Skin Whitening Prescriptions of Traditional Chinese Medicine in Taiwan.Frontiers in pharmacology · 2021Article
- Differential proteomics for studying action mechanisms of traditional Chinese medicines.Chinese medicine · 2019Review
- Wound Healing and the Use of Medicinal Plants.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- A Neutrophil Proteomic Signature in Surgical Trauma Wounds.International journal of molecular sciences · 2018Article
- Integrated metabonomic-proteomic studies on blood enrichment effects of Angelica sinensis on a blood deficiency mice model.Pharmaceutical biology · 2017Article
- Danggui Buxue Extract-Loaded Liposomes in Thermosensitive Gel EnhanceEvidence-based complementary and alternative medicine : eCAM · 2017Article
- From Inflammation to Current and Alternative Therapies Involved in Wound Healing.International journal of inflammation · 2017Review
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angelica sinensis (AS) is a traditional Chinese herbal medicine that has been formulated clinically to treat various form of skin trauma and to help wound healing. However, the mechanism by which it works remains a mystery. In this study we have established a new platform to evaluate the pharmacological effects of total AS herbal extracts as well as its major active component, ferulic acid (FA), using proteomic and biochemical analysis. Cytotoxic and proliferation-promoting concentrations of AS ethanol extracts (AS extract) and FA were tested, and then the cell extracts were subject to 2D PAGE analysis. We found 51 differentially expressed protein spots, and these were identified by mass spectrometry. Furthermore, biomolecular assays, involving collagen secretion, migration, and ROS measurements, gave results that are consistent with the proteomic analysis. In this work, we have demonstrated a whole range of pharmacological effects associated with Angelica sinensis that might be beneficial when developing a wound healing pharmaceutical formulation for the herbal medicine.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.