ArticleEvidence-based complementary and alternative medicine : eCAM2012
Network-based gene expression biomarkers for cold and heat patterns of rheumatoid arthritis in traditional chinese medicine.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Predicting and verifying outcome of Tripterygium wilfordii Hook F. based therapy in rheumatoid arthritis: from open to double-blinded randomized trial.Scientific reports · 2015Trial
- Rheumatoid arthritis characteristics and classification of heat and cold patterns-an observational study.Heliyon · 2023Article
- Epigenetic biomarkers of cold and heat syndromes of rheumatoid arthritis: Combining DNA hydroxymethylation and mRNA-sequencing.International journal of rheumatic diseases · 2023Article
- Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle.Veterinary medicine and science · 2022Article
- Serum metabolomics analysis of deficiency pattern and excess pattern in patients with rheumatoid arthritis.Chinese medicine · 2022Article
- Deciphering Potential Correlations between New Biomarkers and Pattern Classification in Chinese Medicine by Bioinformatics: Two Examples of Rheumatoid Arthritis.Chinese journal of integrative medicine · 2021Article
- Analysis of Colorectal Carcinogenesis Paradigm between Cold Constitution and Heat Constitution: Earlier ECM Collagen Deposition.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Article
- Unsupervised Learning and Multipartite Network Models: A Promising Approach for Understanding Traditional Medicine.Frontiers in pharmacology · 2020Review
- MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2.Cellular & molecular biology letters · 2019Article
- Identification of Characteristic Autoantibodies Associated With Deficiency Pattern in Traditional Chinese Medicine of Rheumatoid Arthritis Using Protein Chips.Frontiers in pharmacology · 2019Article
- Understanding Chinese Medicine Patterns of Rheumatoid Arthritis and Related Biomarkers.Medicines (Basel, Switzerland) · 2018Review
- Clinical Efficacy of Acupuncture on Rheumatoid Arthritis and Associated Mechanisms: A Systemic Review.Evidence-based complementary and alternative medicine : eCAM · 2018Review
- Prediction of cold and heat patterns using anthropometric measures based on machine learning.Chinese journal of integrative medicine · 2018Article
- CytoCluster: A Cytoscape Plugin for Cluster Analysis and Visualization of Biological Networks.International journal of molecular sciences · 2017Article
- ZHENG May Contribute to Obesity Phenotypes Based on Body Composition: A Pilot Study on the Traditional Chinese Medicine Approach.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- Microarray analysis reveals the molecular basis of antiarthritic activity of huo-luo-xiao-ling dan.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Rheumatoid arthritis with deficiency pattern in traditional chinese medicine shows correlation with cold and hot patterns in gene expression profiles.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Navigating traditional chinese medicine network pharmacology and computational tools.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Differences of excess and deficiency zheng in patients with chronic hepatitis B by urinary metabonomics.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IN TRADITIONAL CHINESE MEDICINE (TCM), PATIENTS WITH RHEUMATOID ARTHRITIS (RA) CAN BE CLASSIFIED INTO TWO MAIN PATTERNS: cold-pattern and heat-pattern. This paper identified the network-based gene expression biomarkers for both cold- and heat-patterns of RA. Gene expression profilings of CD4+ T cells from cold-pattern RA patients, heat-pattern RA patients, and healthy volunteers were obtained using microarray. The differentially expressed genes and related networks were explored using DAVID, GeneSpring software, and the protein-protein interactions (PPI) method. EIF4A2, CCNT1, and IL7R, which were related to the up-regulation of cell proliferation and the Jak-STAT cascade, were significant gene biomarkers of the TCM cold pattern of RA. PRKAA1, HSPA8, and LSM6, which were related to fatty acid metabolism and the I-κB kinase/NF-κB cascade, were significant biomarkers of the TCM heat-pattern of RA. The network-based gene expression biomarkers for the TCM cold- and heat-patterns may be helpful for the further stratification of RA patients when deciding on interventions or clinical trials.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.